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Wortmannin, a microbial product inhibitor of myosin light chain kinase.
K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells
K-252a, a kinase inhibitor isolated from the culture broth of Nocardiopsis sp., selectively inhibits the actions of nerve growth factor (NGF) on PC 12 cells. At a concentration of 200 nM, K-252a
Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway
TLDR
This work identified a molecule, CEP-1347 (KT7515), that rescues motoneurons undergoing apoptosis and investigated its effect on ERK1 and JNK1 activity.
K-252a, a potent inhibitor of protein kinase C from microbial origin.
K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent inhibitory activity on protein kinase C. The IC50 value was 32.9 nM.
RES-701-1, a novel, potent, endothelin type B receptor-selective antagonist of microbial origin.
TLDR
The results suggest that RES-701-1 is a potent and specific antagonist for the ETB receptor and that it will be a powerful tool for understanding the physiological roles of this receptor.
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