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K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases.
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.
Wortmannin, a microbial product inhibitor of myosin light chain kinase.
Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.
K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells
- S. Koizumi, M. Contreras, Y. Matsuda, T. Hama, P. Lazarovici, G. Guroff
- Biology, ChemistryThe Journal of neuroscience : the official…
- 1 February 1988
K-252a, a kinase inhibitor isolated from the culture broth of Nocardiopsis sp., selectively inhibits the actions of nerve growth factor (NGF) on PC 12 cells. At a concentration of 200 nM, K-252a…
Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway
This work identified a molecule, CEP-1347 (KT7515), that rescues motoneurons undergoing apoptosis and investigated its effect on ERK1 and JNK1 activity.
Myosin II is involved in transmitter release at synapses formed between rat sympathetic neurons in culture
K-252a, a potent inhibitor of protein kinase C from microbial origin.
K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent inhibitory activity on protein kinase C. The IC50 value was 32.9 nM.
RES-701-1, a novel, potent, endothelin type B receptor-selective antagonist of microbial origin.
The results suggest that RES-701-1 is a potent and specific antagonist for the ETB receptor and that it will be a powerful tool for understanding the physiological roles of this receptor.