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Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP.
The first crystal structure of human GMP reductase 2 in complex with GMP at 3.0 A resolution is reported, and it is proposed that Cys186 is the potential active site, and that the conformation of the loop suggests a preference for the coenzyme NADPH over NADH.