The Pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast
This is the first demonstration that regulated expression of a eukaryotic ABC transporter mediates weak organic acid resistance development, the cause of widespread food spoilage by yeasts, and the data suggest that the inhibition of this transporter could be a strategy for preventingFood spoilage.
Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.
Multiple Pdr1p/Pdr3p Binding Sites Are Essential for Normal Expression of the ATP Binding Cassette Transporter Protein-encoding Gene PDR5*
- D. Katzmann, T. Hallstrom, Y. Mahé, W. Moye-Rowley
- BiologyJournal of Biological Chemistry
- 20 September 1996
Three sites in the PDR5 5′-noncoding region that are closely related to one another and are bound by both Pdr1p and Pdr3p are found and each element is required for wild-type expression and drug resistance.
PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated…
Transcriptional control of the yeast PDR5 gene by the PDR3 gene product
- D. Katzmann, P. Burnett, J. Golin, Y. Mahé, W. Moye-Rowley
- BiologyMolecular and Cellular Biology
- 1 July 1994
Saccharomyces cerevisiae cells possess the ability to simultaneously acquire resistance to an array of drugs with different cytotoxic activities. The genes involved in this acquisition are referred…
RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis.
A model where the Ral-RLIP76 pathway connects signal transduction and endocytosis through interaction on one hand between the Ras-Ral pathway and RLIP, on the other hand between RLIP and proteins belonging to theendocytotic machinery is proposed.
The ATP‐binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3
- Y. Mahé, A. Parle‐McDermott, A. Nourani, A. Delahodde, A. Lamprecht, K. Kuchler
- Biology, EngineeringMolecular Microbiology
- 1 April 1996
It is shown that a pdr1–3 mutant exhibits a PDR phenotype, including elevated resistance to the mutagen 4‐nitroquinoline‐N‐oxide, a known substrate for Snq2 but not for Pdr5, and that the SNQ2 promoter contains three binding sites for PDR3.
Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements.
The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators
The yeast zinc finger regulators Pdr1p and Pdr3p control pleiotropic drug resistance (PDR) as homo‐ and heterodimers in vivo
- Y. Mamnun, R. Pandjaitan, Y. Mahé, A. Delahodde, K. Kuchler
- BiologyMolecular Microbiology
- 1 December 2002
The transcription factors Pdr1p and Pdr3p from Saccharomyces cerevisiae mediate pleiotropic drug resistance (PDR) by controlling expression of ATP‐binding cassette (ABC) transporters such as Pdr5p,…