Y. Ma

Publications27
h-index20
Citations4,404
Highly Influential Citations315
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • M. Lieber
  • 296 Publications, 24,699 Citations
  • F. Alt
  • 646 Publications, 91,677 Citations
  • M. Gellert
  • 123 Publications, 17,463 Citations
  • N. Kleckner
  • 234 Publications, 32,210 Citations
  • Publications
  • Influence
Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination
Mutations in the Artemis protein in humans result in hypersensitivity to DNA double-strand break-inducing agents and absence of B and T lymphocytes (radiosensitive severe combined immune deficiency… Expand
  • 1,087
  • 99
Mechanism and regulation of human non-homologous DNA end-joining
Non-homologous DNA end-joining (NHEJ) — the main pathway for repairing double-stranded DNA breaks — functions throughout the cell cycle to repair such lesions. Defects in NHEJ result in marked… Expand
  • 949
  • 48
  • PDF
Delineation of Joint Molecule Resolution Pathways in Meiosis Identifies a Crossover-Specific Resolvase
At the final step of homologous recombination, Holliday junction-containing joint molecules (JMs) are resolved to form crossover or noncrossover products. The enzymes responsible for JM resolution in… Expand
  • 227
  • 46
A biochemically defined system for mammalian nonhomologous DNA end joining.
Nonhomologous end joining (NHEJ) is a major pathway in multicellular eukaryotes for repairing double-strand DNA breaks (DSBs). Here, the NHEJ reactions have been reconstituted in vitro by using… Expand
  • 332
  • 23
The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis*
Artemis protein has irreplaceable functions in V(D)J recombination and nonhomologous end joining (NHEJ) as a hairpin and 5′ and 3′ overhang endonuclease. The kinase activity of the DNA-dependent… Expand
  • 136
  • 17
Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions.
The Rad2/XPG family nuclease, Exo1, functions in a variety of DNA repair pathways. During meiosis, Exo1 promotes crossover recombination and thereby facilitates chromosome segregation at the first… Expand
  • 194
  • 14
Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV
DNA double‐strand breaks (dsb) during V(D)J recombination of T and B lymphocyte receptor genes are resolved by the non‐homologous DNA end joining pathway (NHEJ) including at least six factors: Ku70,… Expand
  • 172
  • 10
Functional and biochemical dissection of the structure‐specific nuclease ARTEMIS
During V(D)J recombination, the RAG1 and RAG2 proteins form a complex and initiate the process of rearrangement by cleaving between the coding and signal segments and generating hairpins at the… Expand
  • 130
  • 10
Omenn syndrome due to ARTEMIS mutations.
Omenn syndrome (OS) is characterized by severe combined immunodeficiency (SCID) associated with erythrodermia, hepatosplenomegaly, lymphadenopathy, and alopecia. In patients with OS, B cells are… Expand
  • 183
  • 9
  • PDF
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps.
In eukaryotic cells, nonhomologous DNA end joining (NHEJ) is a major pathway for repair of double-strand DNA breaks (DSBs). Artemis and the 469kDa DNA-dependent protein kinase (DNA-PKcs) together… Expand
  • 170
  • 9