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Changes in network activity with the progression of Parkinson's disease.
Parkinson's disease (PD) is associated with abnormal activity in spatially distributed neural systems mediating the motor and cognitive manifestations of this disorder. Metabolic PET studies haveExpand
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Network modulation in the treatment of Parkinson's disease.
It has been proposed that deep brain stimulation (DBS) of the subthalamic nucleus (STN DBS) and dopaminergic therapy ameliorate the symptoms of Parkinson's disease through similar functionalExpand
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Dyskinesia after fetal cell transplantation for parkinsonism: A PET study
Persistent dyskinesias in the absence of or with only minimal amounts of dopaminergic medication have been reported after dopamine cell implantation for Parkinson's disease. In this study, we usedExpand
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Abnormal Metabolic Network Activity in Parkinson'S Disease: Test—Retest Reproducibility
Parkinson's disease (PD) is associated with an abnormal pattern of regional brain function. The expression of this PD-related covariance pattern (PDRP) has been used to assess disease progression andExpand
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Dopamine Cell Implantation in Parkinson's Disease: Long-Term Clinical and 18F-FDOPA PET Outcomes
We have previously reported the results of a 1-y double-blind, placebo-controlled study of embryonic dopamine cell implantation for Parkinson's disease. At the end of the blinded phase, we found aExpand
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Thalamic metabolism and symptom onset in preclinical Huntington's disease.
The neural basis for the transition from preclinical to symptomatic Huntington's disease (HD) is unknown. We used serial positron emission tomography (PET) imaging in preclinical HD gene carriersExpand
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Dissociation of Metabolic and Neurovascular Responses to Levodopa in the Treatment of Parkinson's Disease
We compared the metabolic and neurovascular effects of levodopa (LD) therapy for Parkinson's disease (PD). Eleven PD patients were scanned with both [15O]-H2O and [18F]-fluorodeoxyglucose positronExpand
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Preclinical Huntington's disease: Compensatory brain responses during learning
Motor sequence learning is abnormal in presymptomatic Huntington's disease (p‐HD). The neural substrates underlying this early manifestation of HD are poorly understood. To study the mechanism ofExpand
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Comparative analysis of striatal FDOPA uptake in Parkinson's disease: ratio method versus graphical approach.
UNLABELLED Striatal-to-occipital ratio (SOR) and influx constant K(i)(occ) are commonly used as analytic parameters in L-3,4-dihydroxy-6-(18)F-fluorophenylalanine (FDOPA) PET studies. Both have beenExpand
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Metabolic changes following subthalamotomy for advanced Parkinson's disease
We studied 6 advanced‐stage Parkinson's disease patients with [18F] fluorodeoxyglucose/positron emission tomography before and 3 months after unilateral ablation of the subthalamic nucleus performedExpand
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