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Pharmacokinetics of dexamethasone with pharmacokinetic/pharmacodynamic model of the effect of dexamethasone on endogenous hydrocortisone and cortisone in the horse.
A compartmental model was used to describe the pharmacokinetics of dexamethasone (DXM) and changes in the plasma concentration of endogenous cortisone (COR) and hydrocortisone (HYD) followingExpand
Simultaneous analysis of twenty-one glucocorticoids in equine plasma by liquid chromatography/tandem mass spectrometry.
The method has been successfully applied to screening of a large number of plasma samples obtained from racehorses in competition and in pharmacokinetic studies of dexamethasone in the horse and concurrent changes in endogenous GCC, hydrocortisone and cortisone. Expand
Pharmacokinetics and disposition of clenbuterol in the horse.
The pharmacokinetics of clenbuterol following a single intravenous (i.v.) and oral (p.o.) administration twice daily for 7 days were investigated in thoroughbred horses and the difference between plasma and urinary concentrations of CLB was 100-fold irrespective of the route of administration. Expand
Pharmacokinetics of penicillin G procaine versus penicillin G potassium and procaine hydrochloride in horses.
Results suggest that i.m. administration of penicillin G potassium will result in plasma peniillin G concentrations for 24 hours after drug administration comparable to those obtained with administration of PGP. Expand
Tissue distribution of clenbuterol in the horse.
Accumulation and sustained high concentration of CLB relative to plasma in these tissues contributed to the prolonged elimination and the ability to quantify CLB in plasma and urine for a prolonged period. Expand
Quantification of penicillin-G and procaine in equine urine and plasma using high-performance liquid chromatography.
  • Y. Luo, B. McNamara, +6 authors L. Soma
  • Chemistry, Medicine
  • Journal of chromatography. B, Biomedical sciences…
  • 4 September 1998
A rapid and sensitive method for the extraction and quantification of penicillin-G and procaine in horse urine and plasma samples has been successfully developed. The method involves the use ofExpand
Rapid extraction of clenbuterol from human and calf urine using empore C8 extraction disks.
In the present paper, disk extraction was evaluated for the rapid isolation of clenbuterol from human and calf urine, followed by high-performance liquid chromatography analysis with UV detection. AExpand
[Systematic analysis of basic drugs in plasma using X-5 solid-phase extraction GC-FID and GC-MS].
A systematic determination method for 34 basic drugs in human plasma using X-5 resin as adsorbent and capillary GC-FID and GC-MS are satisfactory for clinical toxicological applications. Expand
[A double column double pH solid phase extraction and capillary GC/FID method for rapid simultaneous determination of acidic and basic drugs in human plasma].
A capillary gas chromatographic method for the rapid simultaneous identification and quantitation of acidic and basic drugs in human plasma is presented. A special double column solid phaseExpand
[Rapid identification and quantitation of barbiturates in plasma using solid-phase extraction combined with GC-FID and GC-MS method].
A rapid screening method for the quantitation and identification of 7 barbiturates in plasma is presented and was satisfactory for blood level monitoring and clinical toxicological applications. Expand