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Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.
The results show sterol-dependent transactivation of the ABC1 promoter by LXR/RXR and suggest that small molecule agonists of LXR could be useful drugs to reverse foam cell formation and atherogenesis. Expand
Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element.
  • Y. Luo, A. Tall
  • Biology, Medicine
  • The Journal of clinical investigation
  • 15 February 2000
The positive sterol response of the CETP gene is mediated by a nuclear receptor binding site that is activated by LXRs, and Cyp7a, the rate-limiting enzyme for conversion of cholesterol into bile acids in the liver, is also regulated by LXRalpha, suggesting that this class of nuclear receptor coordinates the regulation of HDL cholesterol ester catabolism and bile acid synthesis in the Liver. Expand
Three Novel Proteins of the Syntaxin/SNAP-25 Family*
Three novel members of the syntaxin and SNAP-25 (synaptosome-associated protein of 25 kDa) subfamilies are characterized, suggesting a general role in vesicle trafficking, and localize to distinct membrane compartments. Expand
Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B
  • Y. Luo, R. Roeder
  • Medicine, Biology
  • Molecular and cellular biology
  • 1 August 1995
Biochemical purification and cognate cDNA cloning studies have revealed that the previously described transcriptional coactivator OCA-B consists of a 34- or 35-kDa polypeptide with sequenceExpand
TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton*
This is the first time that a GCK family kinase is shown to be potentially involved in the regulation of cytoskeleton and can phosphorylate Gelsolin in vitro. Expand
The structure of human pancreatic α‐amylase at 1.8 Å resolution and comparisons with related enzymes
It is notable that the N‐terminal glutamine residue of human pancreatic α‐amylase undergoes a posttranslational modification to form a stable pyrrolidone derivative that may provide protection against other digestive enzymes. Expand
The Role of Subcellular Localization in Initiation of Apoptosis by Photodynamic Therapy
Evaluating the photodynamic responses to two structurally related photosensitizing agents using the P388 murine leukemia cell line in culture shows results consistent with the hypothesis that membrane photodamage can delay or prevent an apoptotic response to PDT. Expand
Sequence-specific DNA Cleavage by Fe2+-mediated Fenton Reactions Has Possible Biological Implications*
Fe2+-dependent changes in NMR spectra of duplex oligonucleotides containing ATGA versus those containing AUGA or A5mCGA were consistent with this model, and computer modeling of the interaction of Fe2+ with RTGR in B-DNA suggests that due to steric hindrance with the thymine methyl, Fe2+. Expand
Purification, Identification, and Properties of a Saccharomyces cerevisiae Oleate-activated Upstream Activating Sequence-binding Protein That Is Involved in the Activation of POX1(*)
An oleate-activated transcription factor (Oaf1p) that binds to the activating sequence (UAS1) in the POX1 gene is purified and identified, with a predicted molecular mass of approximately 118 kDa. Expand
Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB.
The carboxy-terminal domain of RIP3, like that of RIP, could activate the transcription factor NFkappaB and induce apoptosis when expressed in mammalian cells and appears to function as an intermediary in TNFalpha-induced apoptosis. Expand