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The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans.
  • F. Cao, S. Lane, +5 authors H. Liu
  • Biology, Medicine
  • Molecular biology of the cell
  • 2 November 2005
The transcription factor Flo8 is essential for filamentous growth in Saccharomyces cerevisiae and is regulated under the cAMP/protein kinase A (PKA) pathway. To determine whether a similarExpand
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Hyphal Development in Candida albicans Requires Two Temporally Linked Changes in Promoter Chromatin for Initiation and Maintenance
Phenotypic plasticity is common in development. For Candida albicans, the most common cause of invasive fungal infections in humans, morphological plasticity is its defining feature and is criticalExpand
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Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation
Significance Quorum sensing is a mechanism for intra- and/or interspecies microbial communication of cell density information. It can regulate group behaviors, like virulence, biofilm formation, andExpand
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A GATA Transcription Factor Recruits Hda1 in Response to Reduced Tor1 Signaling to Establish a Hyphal Chromatin State in Candida albicans
Candida albicans is an important opportunistic fungal pathogen of immunocompromised individuals. One critical virulence attribute is its morphogenetic plasticity. Hyphal development requires twoExpand
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Hyphal Chain Formation in Candida albicans: Cdc28-Hgc1 Phosphorylation of Efg1 Represses Cell Separation Genes
ABSTRACT Cell chain formation is a characteristic of filamentous growth in fungi. How it is regulated developmentally in multimorphic fungi is not known. In Candida albicans, degradation of septaExpand
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Candida albicans hyphal initiation and elongation.
The fungus Candida albicans is a benign member of the mucosal microbiota, but can cause mucosal infections and life-threatening disseminated invasive infections in susceptible individuals. TheExpand
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Synergistic regulation of hyphal elongation by hypoxia, CO(2), and nutrient conditions controls the virulence of Candida albicans.
Candida albicans reversibly switches between yeast and hyphal morphologies, with hyphae being associated with virulence. Hyphal initiation and maintenance depend on host environment sensing. HyphalExpand
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Alanine–glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer
Mutations in the alanine–glyoxylate amino transferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads toExpand
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Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity
Many signaling pathways important for hyphal development have been identified, but how Candida albicans coordinates information from these signaling pathways during hyphal development remains a majorExpand
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Acaricidal activity of extracts of neem (Azadirachta indica) oil against the larvae of the rabbit mite Sarcoptes scabiei var. cuniculi in vitro.
The acaricidal activity of the petroleum ether extract, the chloroform extract and the acetic ether extract of neem (Azadirachta indica) oil against Sarcoptes scabiei var. cuniculi larvae was testedExpand
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