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Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro.
The antioxidant mechanism of FEHP might be attributed to its free radical scavenging activity, metal-chelation activity, and reactive oxygen quenching activity, which suggested that chelation of metal ion was the main antioxidant action. Expand
MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor.
Evidence is provided that miR-139 might function as a metastasis suppressor in CRC by targeting type I insulin-like growth factor receptor (IGF-IR) and directing migration inactivation of CRC cells involves down-regulation of matrix metalloproteinase 2 (MMP-2). Expand
Phytochemical profiles of different mulberry (Morus sp.) species from China.
The high contents of functional compounds in mulberry juice, fruits, and leaves implied that they might be potential resources for the development of functional drinks and food. Expand
7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-κB in LPS-stimulated
Results indicated that 7b exhibited anti-inflammatory effects by targeting inhibiting TAK1, leading to ERK1/2- and p38 MAPK-mediated inactivation of NF-κB in LPS-stimulated RAW264.7 cells, and this would make 7b a strong candidate for further study as anti- inflammation agent. Expand
Synthesis of an amino‐terminated hyperbranched polymer and its application in reactive dyeing on cotton as a salt‐free dyeing auxiliary
A water-soluble amino-terminated hyperbranched polymer was synthesised from methyl acrylate and diethylene triamine by melt polycondensation. Its molecular weight and possible structure wereExpand
Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide
It is demonstrated that naringin and nobiletin, even at physiological concentrations, have neuroprotective effects against H(2)O(2)-induced cytotoxicity in PC12 cells, suggesting that these dietary antioxidants are potential candidates for use in the intervention for neurodegenerative diseases. Expand
Hypocholesterolemic effects of a flavonoid-rich extract of Hypericum perforatum L. in rats fed a cholesterol-rich diet.
The results suggested that the hypocholesterolemic effects of FEHP might be due to its abilities to lower serum TC, TG, and LDL-C levels as well as to slow the lipid peroxidation process and to enhance the antioxidant enzyme activity. Expand
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
A series of 1-acyl-1H-[1,2,4]triazole-3,5-diamine analogues were synthesized as cyclin-dependent kinase (CDK) inhibitors. These compounds showed potent and selective CDK1 and CDK2 inhibitoryExpand
Citrus Flavonoids in Fruit and Traditional Chinese Medicinal Food Ingredients in China
LC-ES-MS analysis of Zanthoxylum genus for flavonoids revealed for the first time the presence of significant amounts of hesperidin in the root of Liangmianzhen (Z. Expand
In vitro anti-tumor activity of isorhamnetin isolated from Hippophae rhamnoides L. against BEL-7402 cells.
The cytotoxic effects of isorhamnetin showed dose- and time-dependency against human hepatocellular carcinoma cells (BEL-7402) with the appearance of a hypodiploid peak (sub-G(0)/G(1) peak), probably due to the presence of cells in apoptosis and apoptotic bodies with DNA content less than 2n. Expand