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Ochratoxin A induces apoptosis in neuronal cells
Overall, present data indicated that OTA is neurotoxic at relatively low concentrations and OTA induced neurotoxicity seems to be, at least party, mediated by apoptosis. Expand
A novel anticancer agent, icaritin, induced cell growth inhibition, G1 arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells.
A novel anticancer efficacy of icaritin mediated selectively via induction of cell cycle arrest but not associated with estrogen receptors in PC-3 cells is suggested. Expand
Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line.
  • Zhe Chen, Ke Jin, +4 authors Y. Lou
  • Biology, Medicine
  • European journal of pharmacology
  • 25 September 2010
The results point toward that S phase-related cell cycle regulation, more importantly reactive oxygen species-related apoptosis might contribute to the anticancer properties of bakuchiol, which will strongly support the further development of bAKuchiol against non-small-cell lung cancer. Expand
Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro.
It is found that cardiomyocyte differentiation was efficiently stimulated only if icariin was administrated between days 5 and 8 in differentiation course, which indicated with elevated percentage of embryoid bodies (EB) and with beating areas and up- regulated expression of alpha-actinin and troponin T. Expand
Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.
Asiatic acid protects neurons from C(2)-ceramide-induced cell death by antagonizing mitochondria-dependent apoptosis, and partly counteracted the pro-apoptotic effects of the C-ceramide by reducing the cytosolic release of HtrA2/Omi and the upregulation of Bax and caspase 3. Expand
Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.
  • H. Ye, Y. Lou
  • Chemistry, Medicine
  • Phytomedicine : international journal of…
  • 15 November 2005
Results demonstrate that ICT and DICT (nonconjugated forms) possess estrogen-like activity; however, ICA appears to have no estrogenicity in the MCF-7 cell line model in vitro. Expand
Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells
The results revealed that the significant promoting effects of prenylflavonoids on cardiac differentiation was at least partly via ROS signaling cascades, and the facilitating abilities preferentially based on the nature of preNYlflav onoids themselves, but anti‐oxidative activity determined by the OH numbers and the positions in the structures do influence the cardiomyogenesis in vitro. Expand
Mitochondria are the main target organelle for trivalent monomethylarsonous acid (MMA(III))-induced cytotoxicity.
The mechanism underlying cell death is different among As(III), MMA( III), and DMA(III, with mitochondria being one of the primary target organelles for MMA(III)-induced cytotoxicity. Expand
Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway
It is reported that Rg1 protects primary rat cerebrocortical neurons against β-amyloid peptide injury and ameliorates Aβ₂₅₋₃₁-induced neuronal apoptosis at least in part by two complementary ERα- and GR-dependent downstream pathways. Expand
Generation of thioarsenicals is dependent on the enterohepatic circulation in rats.
The present result of the metabolic balance and speciation study suggests that the formation of MMMTA (V) and DMMTA(V) in rats is dependent on enterohepatic circulation and in vitro experiments indicated that arsenicals excreted from bile may be transformed by gastrointestinal microbiota into MMMMA(V), which are then absorbed into the bloodstream and finally excreting into the urine. Expand