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The carotenoid beta-cryptoxanthin stimulates the repair of DNA oxidation damage in addition to acting as an antioxidant in human cells.
The role of dietary antioxidants in human health remains controversial. Fruits and vegetables in the diet are associated with lower rates of chronic disease, and this is often attributed to theirExpand
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Controlling variation in the comet assay
Variability of the comet assay is a serious issue, whether it occurs from experiment to experiment in the same laboratory, or between different laboratories analysing identical samples. Do we have toExpand
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Can Standard Genotoxicity Tests be Applied to Nanoparticles?
Experiments were conducted to determine the validity of two common genotoxicity testing procedures, the comet assay and the micronucleus (MN) test, when applied to nanoparticles (NP). The comet assayExpand
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Coating-dependent induction of cytotoxicity and genotoxicity of iron oxide nanoparticles
Abstract Surface coatings of nanoparticles (NPs) are known to influence advantageous features of NPs as well as potential toxicity. Iron oxide (Fe3O4) NPs are applied for both medical diagnostics andExpand
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Epithelial cells as alternative human biomatrices for comet assay
The comet assay is a valuable experimental tool aimed at mapping DNA damage in human cells in vivo for environmental and occupational monitoring, as well as for therapeutic purposes, such as storageExpand
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The comet assay, DNA damage, DNA repair and cytotoxicity: hedgehogs are not always dead.
DNA damage is commonly measured at the level of individual cells using the so-called comet assay (single-cell gel electrophoresis). As the frequency of DNA breaks increases, so does the fraction ofExpand
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In vitro comet assay for DNA repair: a warning concerning application to cultured cells.
The comet assay (single-cell gel electrophoresis) is a sensitive and simple method for measuring DNA damage. An early modification of the assay involved the application of specific repairExpand
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Vitamin C in Cultured Human (HeLa) Cells: Lack of Effect on DNA Protection and Repair
Aims: Dietary antioxidants, including vitamin C, may be in part responsible for the cancer-preventive effects of fruits and vegetables. Human intervention trials with clinical endpoints have failedExpand
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Coffee and oxidative stress: a human intervention study
PurposeCoffee is known to contain phytochemicals with antioxidant potential. The aim of this study was to investigate possible antioxidant effects of coffee in healthy human volunteers.MethodsAExpand
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Free circulating mRNA in plasma from breast cancer patients and clinical outcome.
We studied by real-time PCR cyclin D1 and thymidylate synthase (TS) mRNA in plasma as possible markers of clinical outcome in breast cancer. We observed poor outcome in patients with presence ofExpand
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