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ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions
TLDR
Risk of Bias In Non-randomised Studies - of Interventions is developed, a new tool for evaluating risk of bias in estimates of the comparative effectiveness of interventions from studies that did not use randomisation to allocate units or clusters of individuals to comparison groups. Expand
Dissemination and publication of research findings: an updated review of related biases.
TLDR
There was convincing evidence that outcome reporting bias exists and has an impact on the pooled summary in systematic reviews, and empirical evidence suggests that published studies tended to report a greater treatment effect than those from the grey literature. Expand
Risk of Clostridium difficile Infection With Acid Suppressing Drugs and Antibiotics: Meta-Analysis
TLDR
Despite the substantial statistical and clinical heterogeneity, the findings indicate a probable association between PPI use and incident and recurrent CDI, which is further increased by concomitant use of antibiotics and PPI, whereas H2RAs may be less harmful. Expand
Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.
TLDR
Inhaled anticholinergics are associated with a significantly increased risk of cardiovascular death, MI, or stroke among patients with COPD. Expand
Safety of transcranial direct current stimulation: Evidence based update 2016
TLDR
This safety update is inconsistent with the fundamentals of an evidence-based review, also known as a systematic review, and the construction of highly sensitive searches to allow the retrieval of all relevant studies is recommended. Expand
Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis.
TLDR
Among patients with impaired glucose tolerance or type 2 diabetes, rosiglitazone use for at least 12 months is associated with a significantly increased risk of myocardial infarction and heart failure, without a significantlyIncreased risk of cardiovascular mortality. Expand
Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis
TLDR
Long term therapy with aspirin is associated with a significant increase in the incidence of gastrointestinal haemorrhage, and no evidence exists that reducing the dose or using modified release formulations would reduce the incidence. Expand
Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews
TLDR
Investigating basic assumptions and other methodological problems in the application of indirect comparison in systematic reviews of competing healthcare interventions found an unclear understanding of underlying assumptions, inappropriate search and selection of relevant trials, use of inappropriate or flawed methods, and inadequate comparison or inappropriate combination of direct and indirect evidence. Expand
Systematic Review. What is the evidence of the impact of microfinance on the well-being of poor people?
The concept of microcredit was first introduced in Bangladesh by Nobel Peace Prize winner Muhammad Yunus. Professor Yunus started Grameen Bank (GB) more than 30 years ago with the aim of reducingExpand
Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis
TLDR
Long-term thiazolidinedione use doubles the risk of fractures among women with type 2 diabetes, without a significant increase in risk of Fractures among men with type 1 diabetes. Expand
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