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Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
It is found that the glycosaminoglycan hyaluronan accumulates in demyelinated lesions from individuals with multiple sclerosis and in mice with experimental autoimmune encephalomyelitis.
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11, and 14
DSG-2 is identified as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14, which represent key human pathogens causing respiratory and urinary tract infections and may have implications for cancer therapy.
Thyroid hormone action at the cellular, genomic and target gene levels
This review describes studies on TH action from the laboratory examining the cellular localization and motility of TRs using green fluorescent fusion proteins, gene expression profiles of TH in WT and TRalpha and TRbeta KO mice, as well as general transcription factor and co-activator recruitment on the promoters of target genes by TH in chromatin immunoprecipitation assays.
Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity
The data suggest that E/M-MP cells are able to differentiate into different lineages under certain conditions, and have the capacity for self-renewal, i.e. to maintain a subset of undifferentiated E/Cadherinlow/cytoplasmic E-cadher inhigh/CD133high, CD44high, Tie2low, and the expression levels of Tie2, CD133, and CD44.
High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program
This is the first to analyze high-resolution HLA diversities across the entire country of China, based on a detailed and complete data set that covered 31 provinces, autonomous regions, and municipalities and believes it might be useful for unrelated HLA-matched donor searches, donor registry planning, population genetic studies, and anthropogenesis studies.
Self-efficacy and fatigue among non-frontline health care workers during COVID-19 outbreak: A moderated mediation model of posttraumatic stress disorder symptoms and negative coping
More than half non-frontline HCWs suffered from fatigue during COVID-19, and it might be crucial to design programs combining the enhancement of self-efficacy, preventions for PTSD symptoms and interventions for fatigue.
Epithelial phenotype confers resistance of ovarian cancer cells to oncolytic adenoviruses.
It is discovered that the epithelial phenotype of ovarian cancer represents a barrier to infection by commonly used oncolytic adenoviruses targeted to coxsackie-adenovirus receptor or CD46, which provides a venue for improved virotherapy of cancer as well as new insights into cancer cell biology.
Soil respiration and response of carbon source changes to vegetation restoration in the Loess Plateau, China.
  • Peng Shi, Yanli Qin, +6 authors F. Wang
  • Medicine, Environmental Science
    The Science of the total environment
  • 16 November 2019
The results provided a theoretical basis for assessing C balance in terrestrial ecosystems and showed that soil respiration in the rainy season was significantly higher than that in the dry season (P < .05).
N-Acetyl Cysteine Depletes Reactive Oxygen Species and Prevents Dental Monomer-Induced Intrinsic Mitochondrial Apoptosis In Vitro in Human Dental Pulp Cells
Dental monomers induced oxidative stress and mitochondrial intrinsic apoptosis in hDPCs, and N-acetyl cysteine (NAC) restored cell viability, relieved oxidative Stress and blocked the apoptotic effects of dental monomers.
Dual-Mode Imaging-Guided Synergistic Chemo- and Magnetohyperthermia Therapy in a Versatile Nanoplatform To Eliminate Cancer Stem Cells.
Cancer stem cells (CSCs) have been identified as a new target for therapy in diverse cancers. Traditional therapies usually kill the bulk of cancer cells, but are often unable to effectively