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SPECIES- AND DISPOSITION MODEL-DEPENDENT METABOLISM OF RALOXIFENE IN GUT AND LIVER: ROLE OF UGT1A10
Caco-2 cell lysate, and intestinal and liver microsomes derived from female humans and rats were used to compare and contrast the metabolism and disposition of raloxifene. In Caco-2 cell lysate,Expand
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  • Open Access
Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9
  • L. Zhu, Guangbo Ge, +6 authors L. Yang
  • Medicine, Chemistry
  • Xenobiotica; the fate of foreign compounds in…
  • 5 September 2012
Human exposure to magnolol can reach a high dose in daily life. Our previous studies indicated that magnolol showed high affinities to several UDP-glucuronosyltransferases (UGTs) This study wasExpand
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Inhibition of human liver cytochrome P450 by star fruit juice.
PURPOSE To examine the inhibitory effects of star fruit (Averrhoa carambola) juice towards seven major cytochrome P450 (CYP) isoforms and NADPH-cytochrome P450 reductase (CPR). METHODS TheExpand
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A comparison of the ultrastructure and composition of fruits’ cuticular wax from the wild-type ‘Newhall’ navel orange (Citrus sinensis [L.] Osbeck cv. Newhall) and its glossy mutant
Key messageThe altered ultrastructure and composition of cuticular wax from ‘glossy Newhall’ (MT) fruits lead to its glossy phenotype.AbstractA novel mutant derived from the wild-type (WT) ‘Newhall’Expand
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Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-epi-paclitaxel
  • Y. Zhang, Y. Liu, +4 authors L. Yang
  • Medicine, Chemistry
  • Xenobiotica; the fate of foreign compounds in…
  • 1 April 2009
The C-7 chiral centre in paclitaxel is subject to epimerization under physiological conditions, thus making 7-epi-paclitaxel as the principal degradant. This study was designed to characterize theExpand
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Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases
  • Limei Ai, L. Zhu, +5 authors Y. Zhang
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 7 March 2014
Abstract 1. Nilotinib, a tyrosine kinase inhibitor, could potently inhibit SN-38 glucuronidation mainly catalyzed by UDP-glucuronosyltransferase (UGT) 1A1. This study was designed to investigateExpand
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Inhibitory effects of sanguinarine on human liver cytochrome P450 enzymes.
Sanguinarine (SAG) has been recognized as an anticancer drug candidate. However, the drug-drug interactions (DDI) potential for SAG via the inhibition against human cytochrome P450 (CYP) enzymesExpand
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Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation
  • W. Li, Y. Liu, +4 authors L. Yang
  • Chemistry, Medicine
  • Archives of pharmacal research
  • 16 April 2009
Treatment of androgen-independent prostate cancer (AIPC) remains unsatisfactory. In our present experiment, natural occurring ginsenosides (NOGs) and intestinal bacterial metabolites (IBMs) wereExpand
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  • Open Access
UDP-Glucuronosyltransferase 1A6 Is the Major Isozyme Responsible for Protocatechuic Aldehyde Glucuronidation in Human Liver Microsomes
Glucuronidation is an important pathway in the metabolism of protocatechuic aldehyde (3,4-dihydroxybenzaldehyde, PAL). However, the metabolites and primary UDP-glucuronosyltransferase (UGT) isozymesExpand
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  • Open Access
Ranks of Solutions of the Linear Matrix Equation AX + YB = C
  • Y. Liu
  • Mathematics, Computer Science
  • Comput. Math. Appl.
  • 1 September 2006
tl;dr
For a consistent complex matrix equation AX+YB=C, we solve the following two problems:(1)the maximal and minimal ranks of a pair of solutions X and Y to AX+yB= C, and (2) the maximal ranks of four real matrices X"0, X"1, Y"0 and Y"1 in a pairof solutions X=X"0+iX"1 and Y=Y" 0+iY"1 to AX+. Expand
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