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Whisker barrel cortex delta oscillations and gamma power in the awake mouse are linked to respiration
It is reported that delta band oscillation in spike and local field potential activity in the whisker barrel cortex of awake mice is phase locked to respiration, and LFP oscillations in the gamma frequency band are amplitude modulated in phase with the respiratory rhythm. Expand
Opening rate of acetylcholine receptor channels.
The nicotinic acetylcholine (ACh) receptor is responsible for rapid conversion of chemical signals to electrical signals at the neuromuscular junction, and the opening rate is relatively insensitive to voltage. Expand
Hippocampal sharp-wave ripples in awake mice are entrained by respiration
It is shown that the timing of SWR events is modulated by the respiratory cycle, with a significantly increased probability of SWRs during the early expiration phase, which represents a possible neuronal mechanism for a direct influence of the respiratory Cycle on memory function. Expand
Application of the one- and two-dimensional Ising models to studies of cooperativity between ion channels.
The Ising model of statistical physics is applied to the study of cooperative phenomena between ligand-gated ion channels and the sigma 2 versus rho o curve provides unambiguous information about channel interactions. Expand
The lipophilicity, pharmacokinetics, and cellular uptake of different chemically-modified tetracyclines (CMTs).
- Y. Liu, N. Ramamurthy, +5 authors L. Golub
- Chemistry, Medicine
- Current medicinal chemistry
- 31 January 2001
Since CMT-8, as well as CMTs-3 and -1, consistently exhibited the greatest in vivo efficacy in animal models of tissue breakdown, this may reflect, at least in part, their favorable pharmacokinetics and tissue uptake. Expand
Effects of alcohols and volatile anesthetics on the activation of nicotinic acetylcholine receptor channels.
It is concluded that butanol and pentanol increase burst frequency by increase the channel opening rate, whereas ether does so by increasing the agonist binding affinity of the ACh receptor. Expand
Identification of vacuolar phosphate efflux transporters in land plants
Together, these data indicate that this transporter was recruited to the vacuolar membrane to catalyse Pi efflux during the course of land plant evolution, and two new phosphate efflux transporters are shown to be important for phosphate export from the Vacuole in rice and probably other land plants. Expand
A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer’s mouse model via an HSF1-mediated mechanism
It is demonstrated here that chronic treatment with a proprietary Hsp90 inhibitor compound (OS47720) not only elicits a heat-shock-like response but also offers synaptic protection in symptomatic Tg2576 mice, a model of Alzheimer’s disease, without noticeable systemic toxicity. Expand
Opioid and Opiate Immunoregulatory Processes.
The present review provides an overview of recent advances in the field of opiate and opioid immunoregulatory processes and speculates as to their significance in diverse biological systems. Expand
A Chemically Modified Tetracycline (CMT-3) Is a New Antifungal Agent
- Y. Liu, M. Ryan, +5 authors L. Golub
- Medicine, Biology
- Antimicrobial Agents and Chemotherapy
- 1 May 2002
Several chemically modified tetracycline analogs (CMTs), which were chemically modified to eliminate their antibacterial efficacy, were unexpectedly found to have antifungal properties and CMT-3 appeared to have widespread intracellular distribution throughout C. albicans and the Penicillium sp. Expand