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Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
BackgroundTumor-associated macrophages (TAMs) are alternatively activated cells induced by interleukin-4 (IL-4)-releasing CD4+ T cells. TAMs promote breast cancer invasion and metastasis; however,Expand
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Cellular reservoirs of HIV-1 and their role in viral persistence.
A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can escapeExpand
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Nesprin 1 is critical for nuclear positioning and anchorage.
Nesprin 1 is an outer nuclear membrane protein that is thought to link the nucleus to the actin cytoskeleton. Recent data suggest that mutations in Nesprin 1 may also be involved in the pathogenesisExpand
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Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3+ Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms
Combined inhibition of distinct histone deacetylases enhances the suppressive effects of regulatory T cells. Enhancing Regulatory T Cell Function Some therapies designed to help patients sufferingExpand
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Essential role of mitochondrial energy metabolism in Foxp3+ T‐regulatory cell function and allograft survival
Conventional T (Tcon) cells and Foxp3+ T‐regulatory (Treg) cells are thought to have differing metabolic requirements, but little is known of mitochondrial functions within these cell populations inExpand
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Mbd2 Promotes Foxp3 Demethylation and T-Regulatory-Cell Function
ABSTRACT Use of Foxp3-positive (Foxp3+) T-regulatory (Treg) cells as potential cellular therapy in patients with autoimmunity, or post-stem cell or -organ transplantation, requires a soundExpand
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Sirtuin-1 Targeting Promotes Foxp3+ T-Regulatory Cell Function and Prolongs Allograft Survival
ABSTRACT Sirtuin 1 (Sirt1), a class III histone/protein deacetylase, is central to cellular metabolism, stress responses, and aging, but its contributions to various host immune functions have beenExpand
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Loss of Enigma Homolog Protein Results in Dilated Cardiomyopathy
Rationale: The Z-line, alternatively termed the Z-band or Z-disc, is a highly ordered structure at the border between 2 sarcomeres. Enigma subfamily proteins (Enigma, Enigma homolog protein, andExpand
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Single rice growth period was prolonged by cultivars shifts, but yield was damaged by climate change during 1981-2009 in China, and late rice was just opposite.
Based on the crop trial data during 1981-2009 at 57 agricultural experimental stations across the North Eastern China Plain (NECP) and the middle and lower reaches of Yangtze River (MLRYR), weExpand
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Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells.
Lysine ɛ-acetylation is a post-translational modification that alters the biochemical properties of many proteins. The reaction is catalyzed by histone/protein acetyltransferases (HATs), and isExpand
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