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p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding.
TLDR
This model provides a framework for testing mechanisms of p53-mediated apoptosis dependent upon the p53 protein modification state, the level of p 53 protein accumulation, thelevel of DNA damage and the capacity of the damaged cell to repair. Expand
A Second-Stage Genome Scan for QTLs Influencing BMD Variation
TLDR
Two-point and multipoint linkage analyses were performed for each BMD site using statistical genetic methods that are implemented in the computer package SOLAR, and several regions achieved LOD scores in excess of 1 in the second-stage followup study. Expand
Interplay between AAUAAA and the trans-splice site in processing of a Caenorhabditis elegans operon pre-mRNA.
TLDR
The results imply that (1) the AAUAAA consensus controls 3' end formation frequency in C. elegans; (2) theAAUAAA is important in determining SL2 trans-splicing events more than 100 bp downstream; and (3) in some circumstances, 3'end formation may occur by a trans- splicing-dependent mechanism. Expand
Overcoming MDR by ultrasound-induced hyperthermia and P-glycoprotein modulation.
TLDR
The combined effect of USHT and P SC 833 on cytotoxicity of doxorubicin far exceeded that produced by USHT or PSC 833 alone. Expand
P53 regulation and function in normal cells and tumors.
TLDR
A model in which activated forms of p53 carry out transcription-dependent functions in growth arrest and DNA repair which may vary by cell type, while most or all wild type forms ofp53 are capable of binding to damaged DNA is suggested. Expand
Time course analysis and modulating effects of established brain tumor on active-specific immunotherapy.
TLDR
Data support the presence of a strong modulatory effect of tumor on local and systemic antitumoral immune response and reversal of this immunosuppression may be a useful adjunct to tumor vaccine therapy. Expand
Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivity.
TLDR
The observations suggest that the genetic selection for ethanol sensitivity selection for propofol sensitivity was not nearly as intense and presumably involves some different genes. Expand
Conserved Epitopes in the Protein Tyrosine Phosphatase Family of Diabetes Autoantigens
TLDR
Sera from T1D patients for reactivity to IA2 were tested and the majority of sera that bound FLYDA and/or IDA also recognized IA2, raising the possibility that in some cases reactivityto IA2 may have arisen by molecular mimicry. Expand