Share This Author
p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding.
This model provides a framework for testing mechanisms of p53-mediated apoptosis dependent upon the p53 protein modification state, the level of p 53 protein accumulation, thelevel of DNA damage and the capacity of the damaged cell to repair.
Functional quantification of DNA-binding proteins p53 and estrogen receptor in cells and tumor tissues by DNA affinity immunoblotting.
The DNA affinity immunoblotting (DAI) method is designed to measure the activities of multiple sequence-specific DNA-binding proteins simultaneously in lysates of cells or frozen tumor tissues, and offers a new means of molecular profiling and monitoring of p53 and other DNA- binding protein activities in cells and tumors.
Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains
It is shown that TRIM32 is required for the induction of muscle autophagy in atrophic conditions using both in vitro and in vivo mouse models, and a previously unidentified mechanism by which ubiquitin ligases activate autophagic regulators is uncovered.
Sliding into home: facilitated p53 search for targets by the basic DNA binding domain
This work has shown that the presence of two separate DNA binding domains in the p53 gene family is a unique feature of vertebrate p53 proteins that is absent in p63, p73 and p53 homologues in primitive species like squid, Drosophila and Caenorhabdities.
Understanding m6A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins
This work focuses on the mechanisms that YTH proteins recognize m6A and mediate the fate of methylated-RNAs in eukaryotic cells, and provides an update on the various aspects of YTH domain-containing proteins.
P53 regulation and function in normal cells and tumors.
A model in which activated forms of p53 carry out transcription-dependent functions in growth arrest and DNA repair which may vary by cell type, while most or all wild type forms ofp53 are capable of binding to damaged DNA is suggested.