Antitumor agents LVI: the protein synthesis inhibition by genkwadaphnin and yuanhuacine of P-388 lymphocytic leukemia cells.
Two natural products isolated from the plant Daphne genkwa have been shown to possess antileukemic activity in mice. Genkwadaphnin and yuanhuacine were observed to inhibit DNA and protein synthesis…
Inhibition by thiopeptin of ribosomal functions associated with T and G factors.
- T. Kinoshita, Y. Liou, N. Tanaka
- Biology, ChemistryBiochemical and Biophysical Research…
- 20 August 1971
Investigation of sesquiterpene lactones as protein synthesis inhibitors of P-388 lymphocytic leukemia cells.
- Y. Liou, I. Hall, K. Lee, W. Williams, S. Chaney
- Biology, ChemistryBiochimica et Biophysica Acta
- 10 March 1983
Antitumor agents XLII: Comparison of antileukemic activity of helenalin, brusatol, and bruceantin and their esters on different strains of P-388 lymphocytic leukemic cells.
- I. Hall, K. Lee, Y. Imakura
- BiologyJournal of Pharmacy and Science
- 1 October 1981
The study demonstrates the lack of consistency of P-388 lymphocytic leukemia cell lines used in various laboratories and indicates that the inbred strain of mice is a critical factor in the tolerance of drug toxicity and, thus, T/C% obtained.
Screening of isoquinoline alkaloids and their derivatives for antibacterial and antifungal activities.
A screening test of antimicrobial activities for some of the isoquinoline alkaloids and their first and second Hofmann elimination products showed that (+)-actinodaphnine (1) and roemerine methine (26) showed weak effects against two G(-) bacteria (Escherichia coli and Klebsiella pneumonia).
Antitumor agents LIV: The effects of daphnoretin on in vitro protein synthesis of Ehrlich ascites carcinoma cells and other tissues.
Daphnoretin has been shown to suppress Ehrlich ascites carcinoma growth in mice and the inhibition of protein synthesis appears to occur during the elongation step with the drug preferentially binding to free ribosomes not engaged in active protein synthesis.
Cytotoxicity of isoquinoline alkaloids and their N-oxides.
A series of 53 isoquinoline alkaloids and their N-oxides have been tested for their cytotoxicity against A-549, HCT-8, KB, P-388, and L-1210 cells and the results are discussed on the basis of structure-activity relationships.
Antitumor agents XLVIII: Structure-activity relationships of quassinoids as in vitro protein synthesis inhibitors of P-388 lymphocytic leukemia tumor cell metabolism.
- Y. Liou, I. Hall, M. Okano, K. Lee, S. Chaney
- Biology, ChemistryJournal of Pharmacy and Science
- 1 April 1982
Brusatol, bruceantin, and bisbrusatolyl malonate inhibited the formation of the first peptide bond between puromycin and [3H]methionyl-transfer RNA bound to the initiation complex, indicating peptidyl transferase activity is inhibited by the quassinoids in P-388 cells.
The effects of genkwadaphnin and gnidilatidin on the growth of P-388, L-1210 leukemia and KB carcinoma cells in vitro.
- I. Hall, Y. Liou, C. B. Oswald, K. Lee
- Biology, ChemistryEuropean Journal of Cancer and Clinical Oncology
- 1986
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