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Association study of two serotonin 1A receptor gene polymorphisms and fluoxetine treatment response in Chinese major depressive disorders
TLDR
This study tested whether Gly272Asp genetic variants are related to a 4-week fluoxetine antidepressant effect in 222 Chinese major depressive patients and tested the linkage disequilibrium (LD) measurement between HTR1A Gly272 asp and C-1019G polymorphisms, and haplotype analysis was conducted to assess the association between the two markers. Expand
Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females
TLDR
Although the COMT Val158Met genetic polymorphism may play a role in cognitive function, ethnicity and testing method may affect the association, the results demonstrate that subjects bearing the Met/Met homozygote have significantly lower mean P300 latencies than do analogs bearing the Val allele. Expand
Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients.
TLDR
This study found that the COMT val158met polymorphism was not associated with 4-week fluoxetine therapeutic response; however, association analysis showed that patients with the comT(Val/Val) genotype had poorer responses in the eighth week and consistently showed significantly smaller reductions in HAM-D(21) scores in the eight week. Expand
Effects of BDNF polymorphisms on brain function and behavior in health and disease
TLDR
The conflicting results in BDNF genetic studies may result from confounding factors such as age, gender, other environmental factors, sample size, ethnicity and phenotype assessment, and future studies with more homogenous populations, well-controlled confounding factors, and well-defined phenotypes are needed to clarify theBDNF genetic effects on mental diseases and human behaviors. Expand
Differential regulation of neurotrophin S100B and BDNF in two rat models of depression
TLDR
These animal models of depression could be used as valid models to explore the role of S100B underlying major depression, and changes in their levels in patients with neuropsychiatric diseases should be interpreted cautiously. Expand
Association of adiponectin and metabolic syndrome among patients taking atypical antipsychotics for schizophrenia: A cohort study
TLDR
Lower levels of adiponectin and weight gain after taking antipsychotic drugs are associated with higher risk of metabolic syndrome in patients taking atypical antipsychotics. Expand
Association analysis of the dopamine D3 receptor gene ser9gly and brain-derived neurotrophic factor gene val66met polymorphisms with antipsychotic-induced persistent tardive dyskinesia and clinical
TLDR
It is concluded that the BDNF val66met genetic polymorphism may exert its effect on the clinically phenotypic variability after TD has occurred and further replication studies with larger sample size and stringent definition for TD is necessary. Expand
Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response
TLDR
Findings show that TPH2 genetic variants may play a role in MDD susceptibility and in acute therapeutic response to selective serotonin reuptake inhibitors in a Chinese population. Expand
Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response
TLDR
The findings show, for the first time, that SERPINE1 genetic variants may play a role in MDD susceptibility and in the acute therapeutic response to selective serotonin reuptake inhibitors. Expand
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