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- Publications
- Influence
Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway.
- B. H. Choi, C. G. Kim, Y. Lim, S. Y. Shin, Y. Lee
- Chemistry, Medicine
- Cancer letters
- 18 January 2008
Curcumin, a constituent of turmeric, has anti-inflammatory, anti-carcinogenic, and chemopreventive effects in several animal tumor models. The expression of P-glycoprotein (P-gp), encoded by the mdr… Expand
Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos.
- H. Kim, Y. Morimoto, +7 authors H. Kasai
- Biology, Medicine
- Carcinogenesis
- 1 February 2001
We examined 8-hydroxyguanine (8-OH-Gua) formation and 8-OH-Gua repair enzyme activity in pulmonary type-II-like epithelial cells to determine whether oxidative stress induced by asbestos plays a role… Expand
Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells.
- S. Y. Shin, Y. Yong, C. G. Kim, Y. Lee, Y. Lim
- Biology, Medicine
- Cancer letters
- 28 January 2010
The natural flavolignan deoxypodophyllotoxin (DPPT) inhibits tubulin polymerization and induces cell cycle arrest at G(2)/M, followed by apoptosis. However, the precise mechanism of DPPT action is… Expand
p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression.
- B. H. Choi, C. G. Kim, Young-Seuk Bae, Y. Lim, Y. Lee, S. Y. Shin
- Biology, Medicine
- Cancer research
- 1 March 2008
Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by… Expand
The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells.
- S. Y. Shin, Kyoung Sun Lee, +4 authors Y. Lee
- Chemistry, Medicine
- Carcinogenesis
- 1 September 2013
2-Chloro-10-[3(-dimethylamino)propyl]phenothiazine mono hydrochloride (chlorpromazine; CPZ) is an antipsychotic agent that was originally developed to control psychotic disorders. The cytotoxic… Expand
Transcription Factor Egr-1 Is Essential for Maximal Matrix Metalloproteinase-9 Transcription by Tumor Necrosis Factor α
- S. Y. Shin, J. H. Kim, A. Baker, Y. Lim, Y. Lee
- Biology, Medicine
- Molecular Cancer Research
- 23 March 2010
Matrix metalloproteinase-9 (MMP-9) is involved in a wide range of normal and pathologic conditions, including inflammation, tissue repair, tumor invasion, and metastasis. Tumor necrosis factor α… Expand
Targeting Cancer Cells via the Reactive Oxygen Species-Mediated Unfolded Protein Response with a Novel Synthetic Polyphenol Conjugate
- S. Y. Shin, J. Lee, +4 authors Y. Lee
- Biology, Medicine
- Clinical Cancer Research
- 17 June 2014
Purpose: The selective killing of tumor cells is an important strategy for cancer therapeutics. The aim of this study was to develop a novel antitumor agent that is safe for normal cells with the… Expand
Structure determination of a sildenafil analogue contained in commercial herb drinks
- C. Shin, Mooki Hong, Daibyung Kim, Y. Lim
- Chemistry, Medicine
- Magnetic resonance in chemistry : MRC
- 1 December 2004
It was found from HPLC analysis that a commercial herb drink contains a putative sildenafil analog. In order to identify the sildenafil‐like compound, separation and purification were carried out.… Expand
2'-Hydroxyflavanone induces apoptosis through Egr-1 involving expression of Bax, p21, and NAG-1 in colon cancer cells.
- S. Y. Shin, J. H. Kim, J. Lee, Y. Lim, Y. Lee
- Biology, Medicine
- Molecular nutrition & food research
- 1 May 2012
SCOPE
Natural flavanones exhibit cancer preventive and/or therapeutic effects. The objective of this study was to investigate the molecular mechanism underlying the action of the antitumor activity… Expand
TNFα-exposed Bone Marrow-derived Mesenchymal Stem Cells Promote Locomotion of MDA-MB-231 Breast Cancer Cells through Transcriptional Activation of CXCR3 Ligand Chemokines*
- S. Y. Shin, Jeong-Seok Nam, Y. Lim, Y. Lee
- Biology, Medicine
- The Journal of Biological Chemistry
- 22 July 2010
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are often recruited to solid tumors, integrate into the tumor stroma, and contribute to tumor development. TNFα is a major inflammatory cytokine… Expand