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The genome of Aiptasia, a sea anemone model for coral symbiosis
The assembly and analysis of the Aiptasia genome is reported on, which will provide a foundation for future studies and has revealed several features that may be key to understanding the evolution and function of the endosymbiosis. Expand
Genomes of coral dinoflagellate symbionts highlight evolutionary adaptations conducive to a symbiotic lifestyle
Comparative analyses of genome and transcriptome protein sets show that all dinoflagellates, not only Symbiodinium, possess significantly more transmembrane transporters involved in the exchange of amino acids, lipids, and glycerol than other eukaryotes. Expand
Integrating microRNA and mRNA expression profiling in Symbiodinium microadriaticum, a dinoflagellate symbiont of reef-building corals
Identification and characterization of Symbiodinium's smRNA repertoire establishes the possibility of a range of gene regulatory mechanisms in dinoflagellates acting post-transcriptionally, and identified a variety of processes that could be under microRNA control. Expand
Comparative genomics explains the evolutionary success of reef-forming corals
Transcriptome and genome data from twenty stony coral species and a selection of reference bilaterians were studied to elucidate coral evolutionary history. We identified genes that encode theExpand
Identification of MicroRNAs in the Coral Stylophora pistillata
First evidence of a functional RNAi machinery and five conserved miRNAs in S. pistillata is presented, implying that miRNAAs play a role in organismal biology of scleractinian corals and potential roles in symbiosis and coral calcification are suggested. Expand
DNA Methylation Cancer Biomarkers: Translation to the Clinic
Existing DNA methylation cancer biomarkers used in clinical practice are summarized, technical factors such as the analytical performance and product-market fit, factors that contribute to successful downstream investment, including geography, and how this impacts intellectual property, regulatory hurdles, and the future of the marketplace and healthcare system are discussed. Expand
Intergenerational epigenetic inheritance in reef-building corals
A role of DNA methylation in the transgenerational inheritance of traits in corals may extend to enhancing their capacity to adapt to climate change, and this work demonstrates genome-wide intergenerational transmission of CpG methylation patterns from parents to sperm and larvae in a reef-building coral. Expand
Epigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coral
Analysis of DNA methylation patterns of corals subjected to long-term pH stress showed widespread changes in pathways regulating cell cycle and body size, which suggest an epigenetic component in phenotypic acclimatization that provides corals with an additional mechanism to cope with environmental change. Expand
DNA methylation regulates transcriptional homeostasis of algal endosymbiosis in the coral model Aiptasia
It is demonstrated that DNA methylation provides an epigenetic mechanism of transcriptional homeostasis that responds to symbiosis and shows enrichment for symbiosis-related processes, such as immunity, apoptosis, phagocytosis recognition, and phagosome formation, and reveal intricate interactions between the underlying pathways. Expand
Multi-omics analysis of thermal stress response in a zooxanthellate cnidarian reveals the importance of associating with thermotolerant symbionts
It is indicated that RS anemones do not show increased antioxidant capacity but may have adapted to higher temperatures through association with more thermally tolerant symbionts. Expand