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ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome.
Promoter hypermethylation of FBXO32, a novel TGF-β/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer
The novel tumor suppressor FBXO32 is epigenetically silenced in ovarian cancer cell lines with disrupted TGF-β/SMAD4 signaling, and FBX O32 methylation status predicts survival in patients with ovarian cancer.
Quantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse
DNA methylation may be used a potential biomarker for detecting cervical cancer in a full spectrum of cervical lesions to test its potential clinical application.
Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer
Evidence is reported of the overexpression of DNA methyltransferases 3B (DNMT3B) in invasive cervical cancer and of the inhibition of metastasis by DN MT3B interference.
Triage of cervical cytological diagnoses of atypical squamous cells by DNA methylation of paired boxed gene 1 (PAX1)
- T. Chao, Feng-Yi Ke, Y. Liao, Hui‐Chen Wang, Cheng-Ping Yu, H. Lai
- MedicineDiagnostic cytopathology
- 1 January 2013
It is shown for the first time that PAX1 hypermethylation analysis may be a better choice than HC2 in the triage of ASCUS and ASC‐H and compared its performance with Hybrid Capture 2 (HC2) HPV test.
LIM-homeobox transcription factor 1, alpha (LMX1A) inhibits tumourigenesis, epithelial-mesenchymal transition and stem-like properties of epithelial ovarian cancer.
Methylomics analysis identifies epigenetically silenced genes and implies an activation of β‐catenin signaling in cervical cancer
The concurrent methylation of multiple genes in cancers and in subsets of precancerous lesions suggests the presence of a driver of methylation phenotype in cervical carcinogenesis.
Methylomic Analysis Identifies Frequent DNA Methylation of Zinc Finger Protein 582 (ZNF582) in Cervical Neoplasms
This study shows ZNF582 is frequently methylated in CIN3 and worse lesions, and it is demonstrated as a potential biomarker for the molecular screening of cervical cancer.
High Methylation Rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 Genes in Cervical Adenocarcinoma
- Cheng-Chang Chang, Rui-Lan Huang, Hui‐Chen Wang, Y. Liao, Mu‐Hsien Yu, H. Lai
- MedicineInternational journal of gynecological cancer…
- 1 February 2014
Cervical ACs carry aberrantly high methylation rates of PAX1, PTPRR, SOX1, and ZNF582—commonly methylated in squamous cell carcinomas—which might help for AC screening.
Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm
Methylation biomarker analysis of the three genes for detection of CIN3+ lesions shows reasonable to good concordance between the self-col collected and physician-collected samples, and self-collection of samples could be adopted to decrease non-attendance and improve cervical screening.