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Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown.… Expand
The EGFR/miR-338-3p/EYA2 axis controls breast tumor growth and lung metastasis
Dysregulation of the epidermal growth factor receptor (EGFR) promotes cancer cell growth, invasion and metastasis. However, its relevant downstream effectors are still limited. Here, we show that… Expand
miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.
Lactate dehydrogenase A (LDHA), a key enzyme regulating aerobic glycolysis, is overexpressed in many human cancers, and correlates with poor clinical outcomes. Aerobic glycolysis is a hallmark of… Expand
HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion
Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was shown to play a role in cancer development and progression. However, the role of HPIP in colorectal cancer… Expand
The IL-1β/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis
The proinflammatory cytokine interleukin-1β (IL-1β) is involved in the initiation and progression of osteoarthritis (OA) by stimulating the expression of matrix-degrading proteinases, such as a… Expand
miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage
- Q. Ji, Xiaojie Xu, +10 authors Yan Wang
- Chemistry, Medicine
- Journal of Molecular Medicine
- 27 January 2016
Fibroblast growth factor 2 (FGF2) plays an important role in the development of osteoarthritis (OA) through the regulation of cartilage degradation. However, the molecular mechanism underlying… Expand
Hematopoietic pre-B cell leukemia transcription factor interacting protein is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration, and invasion
Hematopoietic pre‐B cell leukemia transcription factor interacting protein (HPIP) has been shown to play an important role in the development and progression of some cancers. However, the role of… Expand
A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
Tumour radiotherapy resistance involves the cell cycle pathway. CDC25 phosphatases are key cell cycle regulators. However, how CDC25 activity is precisely controlled remains largely unknown. Here, we… Expand
Raddeanoside R13 inhibits breast cancer cell proliferation, invasion, and metastasis
Pulsatilla chinensis is one of the 50 famous fundamental herbs used in traditional Chinese medicine. Saponins are the main components of P. chinensis. Although the anti-proliferative function of… Expand
[The expression, purification and characterization of human His-ATG4B protein].
- R. Huang, X. Xu, +5 authors Q. Ye
- Biology, Medicine
- Xi bao yu fen zi mian yi xue za zhi = Chinese…
- 1 February 2015
OBJECTIVE To construct the prokaryotic expression vector of human autophagy-related protein 4 homolog B (ATG4B) labeled with His-tag, obtain the purified His-ATG4B protein, and identify its activity… Expand