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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response
Profiling candidate therapeutics with limited cancer models during preclinical development hinders predictions of clinical efficacy and identifying factors that underlie heterogeneous patient… Expand
Primary pulmonary lymphoepithelioma‐like carcinoma
Pulmonary lymphoepithelioma‐like carcinoma (LELC) is a rare kind of cancer.
The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice
- Y. Liang, M. Jansen, B. Aronow, H. Geiger, G. V. Zant
- Biology, Medicine
- Nature Genetics
- 14 January 2007
We mapped quantitative trait loci that accounted for the variation in hematopoietic stem cell (HSC) numbers between young adult C57BL/6 (B6) and DBA/2 (D2) mice. In reciprocal chromosome 3 congenic… Expand
Gefitinib alone or with concomitant whole brain radiotherapy for patients with brain metastasis from non-small-cell lung cancer: a retrospective study.
BACKGROUND Gefitinib, a tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR), is used both as a single drug and concurrently with whole brain radiotherapy (WBRT) the standard… Expand
Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells.
To test the hypothesis that aging has negative effects on stem-cell homing and engraftment, young or old C57BL/6 bone marrow (BM) cells were injected, using a limiting-dilution, competitive… Expand
A Security Ontology with MDA for Software Development
A new ontology for software development has been defined together with MDA that has been used in software development so that security concerns and concepts can play a role in each of stages of the development process and be included as security components in software. Expand
Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance.
- Shu-chen Liu, N. Tsang, +6 authors Y. Chang
- The Journal of clinical investigation
- 2 December 2013
Radioresistance of EBV-associated nasopharyngeal carcinoma (NPC) is associated with poor prognosis for patients with this form of cancer. Here, we found that NPC patients had increased serum levels… Expand
Enhanced Interferon Signaling Pathway in Oral Cancer Revealed by Quantitative Proteome Analysis of Microdissected Specimens Using 16O/18O Labeling and Integrated Two-dimensional LC-ESI-MALDI Tandem…
- Lang-Ming Chi, Chien-Wei Lee, +12 authors Jau-Song Yu
- Biology, Medicine
- Molecular & Cellular Proteomics
- 18 March 2009
Oral squamous cell carcinoma (OSCC) remains one of the most common cancers worldwide, and the mortality rate of this disease has increased in recent years. No molecular markers are available to… Expand
Overexpression of Activin A in Oral Squamous Cell Carcinoma: Association with Poor Prognosis and Tumor Progression
BackgroundBoth activin A, a member of transforming growth factor β superfamily, and its inhibitor follistatin have been shown to be overexpressed in various cancers. We examined the potential role of… Expand
Genome-wide association mapping and Identification of candidate genes for fatty acid composition in Brassica napus L. using SNP markers
BackgroundB. napus (oilseed) is an important source of edible vegetable oil, and its nutritional and economic value is determined by its fatty acid composition and content.ResultsUsing the Brassica… Expand