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1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1.
- Ray T. Syvitski, Y. Li, Karine Auclair, P. R. Ortiz de Montellano, G. L. La Mar
- Chemistry, Medicine
- Journal of the American Chemical Society
- 8 November 2002
Solution 1H NMR is used to probe the environments of the donor protons of eight strong hydrogen bonds on the distal side of the heme substrate in the cyanide-inhibited, substrate-bound complex of… Expand
Solution 1H, 15N NMR spectroscopic characterization of substrate-bound, cyanide-inhibited human heme oxygenase: water occupation of the distal cavity.
- Y. Li, Ray T. Syvitski, Karine Auclair, P. R. Ortiz de Montellano, G. L. La Mar
- Chemistry, Medicine
- Journal of the American Chemical Society
- 10 October 2003
A solution NMR spectroscopic study of the cyanide-inhibited, substrate-bound complex of uniformly (15)N-labeled human heme oxygenase, hHO, has led to characterization of the active site with respect… Expand
Two New Nitrone Alkaloids from Huperzia serrata
- Wenyun Gao, Y. Li, Shanhao Jiang, D. Zhu
- Chemistry
- 1 June 2008
Two new nitrone alkaloids were isolated from the whole plant of Huperzia serrata (Thunb.) Trev. They are both phlegmarine-type lycopodium alkaloids with a nitrone moiety. Their structures were… Expand
A site-specific genomic integration strategy for sustained expression of glucagon-like peptide-1 in mouse muscle for controlling energy homeostasis.
- R. Liu, Y. Li, +9 authors Qinghua Wang
- Biology, Medicine
- Biochemical and biophysical research…
- 10 December 2010
The incretin hormone glucagon-like peptide-1 (GLP-1) exerts important functions in controlling glucose and energy homeostasis. Endogenous GLP-1 has a very short half-life due to DPP-IV-mediated… Expand
Iridoid and phenylpropanoid glycosides of Scrophularia ningpoensis inhibit the formation of LTB_(4) and platelet aggregation
- Y. Li, Hua-wu Zeng, X. He, Yuanying Jiang, Shan-hao Jiang, D. Zhu
- Chemistry
- 1999
- 6
- 1
Chiral-recognition chromatography of β-blockers on continuous polymer beds with immobilized cellulase as enantioselective protein
- J. Mohammad, Y. Li, Mostafa El‐Ahmad, Kenichi Nakazato, G. Pettersson, Stellan Hjertéean
- Chemistry
- 1993
Columns prepared by coupling cellulase as a chiral selector to silica beads are very efficient for the separation of enantiomers. In this paper we show that continuous polymer beds compete favorably… Expand
Solution NMR Characterization of an Unusual Distal H-bond Network in the Active Site of the Cyanide-inhibited, Human Heme Oxygenase Complex of the Symmetric Substrate, 2,4-Dimethyldeuterohemin* 210
- Y. Li, Ray T. Syvitski, Karine Auclair, A. Wilks, P. R. Ortiz de Montellano, G. L. La Mar
- Medicine, Chemistry
- The Journal of Biological Chemistry
- 6 September 2002
The presence of variable static hemin orientational disorder about the α-γ-meso axis in the substrate complexes of mammalian heme oxygenase, together with the incomplete averaging of a second,… Expand
Solution 1H NMR Investigation of the Active Site Molecular and Electronic Structures of Substrate-bound, Cyanide-inhibited HmuO, a Bacterial Heme Oxygenase fromCorynebacterium diphtheriae * 210
- Y. Li, Ray T. Syvitski, G. C. Chu, M. Ikeda-Saito, G. Mar
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 28 February 2003
The molecular structure and dynamic properties of the active site environment of HmuO, a heme oxygenase (HO) from the pathogenic bacterium Corynebacterium diphtheriae, have been investigated by 1H… Expand
Solution structure of BmP01 from the venom of scorpion Buthus martensii Karsch.
- G. Wu, Y. Li, +4 authors Houming Wu
- Chemistry, Medicine
- Biochemical and biophysical research…
- 5 October 2000
From the venom of scorpion Buthus martensii Karsch,a short peptide (BmP01, 29 amino acid residues) was isolated and characterized as previously reported (Lebren, R. R., et al. (1997) Eur. J. Biochem.… Expand
1H NMR Investigation of the Solution Structure of Substrate-free Human Heme Oxygenase
- Y. Li, Ray T. Syvitski, Karine Auclair, P. O. D. de Montellano, G. L. La Mar
- Chemistry, Medicine
- Journal of Biological Chemistry
- 12 March 2004
1H NMR was used to investigate the molecular structure, and dynamic properties of soluble, recombinant, substrate-free human heme oxygenase (apohHO) on a comparative basis with similar studies on the… Expand