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Sparse whole genome sequencing identifies two loci for major depressive disorder
Using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, two loci contributing to risk of MDD on chromosome 10 are identified: one near the SIRT1 gene and the other in an intron of the LHPP gene. Expand
Arabidopsis ABA INSENSITIVE4 Regulates Lipid Mobilization in the Embryo and Reveals Repression of Seed Germination by the Endosperm[W]
It is concluded that the single cell endosperm layer plays an active role in the regulation of seed germination in Arabidopsis and that ABA signaling mutants demonstrate the spatial specificity of ABA action in Seed germination. Expand
Cell Proteins TIA-1 and TIAR Interact with the 3′ Stem-Loop of the West Nile Virus Complementary Minus-Strand RNA and Facilitate Virus Replication
Reconstitution of the TIAR knockout cells with TIAR increased the efficiency of WNV growth, but neither the level of TIAR nor WNV replication was as high as in control cells, which suggest a functional role for TIAR and possibly also for TIA-1 during W NV replication. Expand
AAV Vector Integration Sites in Mouse Hepatocellular Carcinoma
It is shown that normal mice and mice with mucopolysaccharidosis VII (MPS VII) develop hepatocellular carcinoma (HCC) after neonatal injection of an AAV vector expressing b-glucuronidase, which implicate this locus in the development of HCC and raise concerns over the clinical use of AAV vectors. Expand
Agrobacterium tumefaciens-mediated transformation of Beauveria bassiana using an herbicide resistance gene as a selection marker.
A simple, highly efficient and reliable Agrobacterium-mediated transformation method for B. bassiana using a phosphinothricin acetyltransferase (bar) gene as a selectable marker is developed and two putative T-DNA-tagged mutants that may have altered growth habits or virulence are obtained. Expand
Divergent Regulation of Terpenoid Metabolism in the Trichomes of Wild and Cultivated Tomato Species1[W][OA]
The diversification of chemical production in glandular trichomes is important in the development of resistance against pathogens and pests in two species of tomato. We have used genetic and genomicExpand
Molecular insight into lignocellulose digestion by a marine isopod in the absence of gut microbes
This study reports that analysis of ESTs from the digestive system of Limnoria quadripunctata reveals a transcriptome dominated by glycosyl hydrolase genes, and proposes that limnoriid GH7 genes are important for the efficient digestion of lignocellulose in the absence of gut microbes. Expand
Is trehalose-6-phosphate a regulator of sugar metabolism in plants?
There is mounting evidence that trehalose-6-phosphate is implicated in the regulation of sugar metabolism, and further work is necessary to confirm this hypothesis and determine the underlying mechanism. Expand
Organization and Expression Strategy of the Ambisense Genome of Densonucleosis Virus of Galleria mellonella
Despite the transcription and translation strategies being radically different from those of vertebrate parvoviruses, the capsid was found to have phospholipase A2 activity, a feature thus far unique for parviviruses. Expand
Expression of the Auxin-Inducible GH3 Promoter/GUS Fusion Gene as a Useful Molecular Marker for Auxin Physiology
The data presented in this report indicate that expression of the GH3/GUS gene is an excellent molecular marker for studying auxin transport and for monitoring changes in either auxin concentration or cellular sensitivity to auxin in planta. Expand