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A clathrin/dynamin- and mannose-6-phosphate receptor–independent pathway for granzyme B–induced cell death
The 280-kD cation-independent mannose-6-phosphate receptor (MPR) has been shown to play a role in endocytic uptake of granzyme B, since target cells overexpressing MPR have an increased sensitivityExpand
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A murine model of antibody-mediated hyperacute rejection by galactose-alpha(1,3)galactose antibodies in Gal o/o mice.
BACKGROUND In pig-to-primate/human xenografts, hyperacute rejection of primarily vascularized organs usually occurs in 10-60 min and is due to the reaction of the recipients' natural antibodies withExpand
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Treatment of Psoriasis with Mesenchymal Stem Cells.
Full Text Images References Article Tools PDF (422 KB) Download Images(.ppt) About Images & Usage Email Article Add to My Reading List Export Citation Create Citation Alert Cited by in Scopus (9)Expand
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Background. Wehave previously described the rejection of Gal+ mouse hearts by mice lacking Gal&agr;(1,3)Gal (Gal-/-) and demonstrated this to be a model of xenogeneic hyperacute rejection (HAR) whichExpand
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Local expression of IDO, either alone or in combination with CD40Ig, IL10 or CTLA4Ig, inhibits indirect xenorejection responses.
BACKGROUND To overcome cell-mediated xenorejection by transgenic expression of immunomodulatory molecules by a graft, it is likely that expression of multiple molecules will be required. PreviousExpand
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Inhibition of hyperacute transplant rejection by soluble proteins with the functional domains of CD46 and FcgammaRII.
BACKGROUND Recombinant soluble forms of complement regulatory molecules, including the human complement regulatory protein CD46 (rsCD46), have been shown to inhibit hyperacute transplant rejectionExpand
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Dendritic cells expressing soluble CTLA4Ig prolong antigen‐specific skin graft survival
Dendritic cells (DCs) and CTLA4Ig are important in regulating T‐cell responses and therefore represent potential therapeutic tools in transplantation. In this study, CTLA4Ig was expressed in aExpand
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CD46 protects pig islets from antibody but not cell-mediated destruction in the mouse.
We have previously reported that islets present in cultured fetal pig pancreas (FPP) are resistant to destruction by Galalpha(1,3)Gal antibodies and compliment, but are susceptible to the 'secondary'Expand
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Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling.
Hepatocellular carcinoma (HCC) results in large amounts of deaths each year worldwide. To develop more effective treatments for HCC, it is very necessary to define the molecular mechanisms inExpand
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Effect of IL‐4 deletion on cardiac allograft survival in the BALB/c to 129Sv × C57BL/6 strain combination
To investigate the effect of IL‐4 deletion on cardiac allograft survival, vascularized BALB/c cardiac allografts were placed in C57BL/6, 129Sv × C57BL/6 (IL‐4 +/+) or 129Sv × C57BL/6 IL‐4 knockoutExpand
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