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Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab
Although programmed death-ligand 1–programmed death 1 (PD-L1–PD-1) inhibitors are broadly efficacious, improved outcomes have been observed in patients with high PD-L1 expression or high tumor… Expand
Venetoclax–Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia
BACKGROUND Venetoclax inhibits BCL2, an antiapoptotic protein that is pathologically overexpressed and that is central to the survival of chronic lymphocytic leukemia cells. We evaluated the efficacy… Expand
Trends in survival after in-hospital cardiac arrest.
- S. Girotra, B. Nallamothu, J. Spertus, Y. Li, H. Krumholz, P. Chan
- The New England journal of medicine
- 14 November 2012
BACKGROUND Despite advances in resuscitation care in recent years, it is not clear whether survival and neurologic function after in-hospital cardiac arrest have improved over time. METHODS We… Expand
Prevalence and predictors of osteopenia and osteoporosis in postmenopausal Chinese women with type 2 diabetes.
- Y. Zhou, Y. Li, D. Zhang, J. Wang, Hongwu Yang
- Diabetes research and clinical practice
- 1 December 2010
AIMS To determine the prevalence and biochemical/hormonal determinants of osteopenia/osteoporosis in postmenopausal Chinese women with type 2 diabetes. METHODS This cross-sectional study was… Expand
Venetoclax Plus Rituximab Is Superior to Bendamustine Plus Rituximab in Patients with Relapsed/ Refractory Chronic Lymphocytic Leukemia - Results from Pre-Planned Interim Analysis of the Randomized…
Microarray expression profile of circular RNAs and mRNAs in children with systemic lupus erythematosus
BackgroundRecently, it was reported that circular RNAs (circRNAs) play the crucial role in many physiological and biological processes and can be used as biomarkers. However, the information about… Expand
The value of diffusion kurtosis magnetic resonance imaging for assessing treatment response of neoadjuvant chemoradiotherapy in locally advanced rectal cancer
ObjectivesTo evaluate the feasibility and value of diffusion kurtosis (DK) imaging in assessing treatment response to neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal… Expand
[Laparoscopic anatomical nerve sparing radical hysterectomy for cervical cancer: a clinical analysis of 37 cases].
OBJECTIVE To investigate feasibility of laparoscopic anatomical nerve sparing radical hysterectomy (LANSRH) used for locally advanced cervical cancer treatment and evaluate early recovery of bladder… Expand
Olmsted syndrome: a case report and review of literature
We report a case of an 18‐month‐old boy with slightly whitened fingernails and toenails since birth. At the age of 100 days, he progressively developed bilateral palmoplantar keratoderma which… Expand
Palmitate induces H9c2 cell apoptosis by increasing reactive oxygen species generation and activation of the ERK1/2 signaling pathway.
- Chuan-dong Wei, Y. Li, Hong-yun Zheng, Yong-qing Tong, W. Dai
- Biology, Medicine
- Molecular medicine reports
- 1 March 2013
Cardiac myocytes undergo apoptosis under conditions of high free fatty acid concentrations, including palmitate, which is implicated in lipotoxic cardiomyopathy. However, the… Expand