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Identification of a Human Mitotic Checkpoint Gene: hsMAD2
TLDR
Human homolog of MAD2 was isolated and shown to be a necessary component of the mitotic checkpoint in HeLa cells by antibody electroporation experiments, suggesting that MAD2 might monitor the completeness of the spindle-kinetochore attachment. Expand
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function
TLDR
A model in which low-complexity (LC) domains of FUS drive its physiologically reversible assembly into membrane-free, liquid droplet and hydrogel-like structures mitigates neurotoxicity is proposed and suggests a potential therapeutic strategy that may also be applicable to ALS/FTD associated with mutations in other RNA binding proteins. Expand
Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery
TLDR
Neurologic benefit resulting from hMSC treatment of stroke in rats may derive from the increase of growth factors in the ischemic tissue, the reduction of apoptosis in the penumbral zone of the lesion, and the proliferation of endogenous cells in the subventricular zone. Expand
Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation
TLDR
The data suggest that transplantation of MSCs may have a therapeutic role after spinal cord injury, and indicate significant improvement in functional outcome in animals treated with MSC transplantation compared to control animals. Expand
Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat
  • J. Chen, Y. Li, +6 authors M. Chopp
  • Biology, Medicine
  • Journal of neuroscience research
  • 15 September 2003
TLDR
It is demonstrated that intravenously administered male MSCs increase bFGF expression, reduce apoptosis, promote endogenous cellular proliferation, and improve functional recovery after stroke in female rats. Expand
Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate
TLDR
The ability of DRN neurons to organize reward behaviors is demonstrated and might provide insights into the underlying mechanisms of learning facilitation and anhedonia treatment. Expand
Intravenous Administration of Human Bone Marrow Stromal Cells Induces Angiogenesis in the Ischemic Boundary Zone After Stroke in Rats
TLDR
Treatment of stroke with hMSCs enhances angiogenesis in the host brain and hMSC-enhanced angiogenic is mediated by increases in levels of endogenous rat VEGF and VEGFR2. Expand
MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity.
TLDR
MAD2, an essential component of the mitotic checkpoint, associates with the cyclin B-ubiquitin ligase, known as the cyclosome or anaphase-promoting complex, and causes a metaphase arrest in cycling Xenopus laevis egg extracts and prevents Cyclin B proteolysis by blocking its ubiquitination, indicating that MAD2 functions as an inhibitor of the cyclOSome. Expand
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
TLDR
The results suggest that mammary stem cells and/or progenitors to mammary luminal epithelial and myoepithelial cells may be the targets for oncogenesis by Wnt-1 signaling elements. Expand
A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
TLDR
It is shown that inhibition of TAK1 in mice by a cardiac-specific dominant-negative mutation evokes electrophysiological and biochemical properties reminiscent of human Wolff–Parkinson–White syndrome, arising from mutations in AMP-activated protein kinase (AMPK), most notably, accelerated atrioventricular conduction and impaired AMPK activation. Expand
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