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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by the formation of hamartomas in a wide range of human tissues. Mutation in either the TSC1 or TSC2 tumour suppressor gene is… Expand
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either TSC1 or TSC2. The TSC1 and TSC2 gene products form a functional complex and inhibit phosphorylation of S6K and… Expand
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the utilization of fat as an energy source during starvation and is the molecular target for the fibrate dyslipidemia drugs.… Expand
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but how the fusion products… Expand
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene.
MicroRNA-155 (miR-155) is overexpressed in many human cancers; however, the mechanisms by which miR-155 functions as a putative oncomiR are largely unknown. Here, we report that the tumor suppressor… Expand
A novel miR‐155/miR‐143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
Cancer cells preferentially metabolize glucose through aerobic glycolysis. This phenomenon, known as the Warburg effect, is an anomalous characteristic of glucose metabolism in cancer cells. Chronic… Expand
Signaling by Target of Rapamycin Proteins in Cell Growth Control
- K. Inoki, H. Ouyang, Y. Li, K. Guan
- Medicine, Biology
- Microbiology and Molecular Biology Reviews
- 1 March 2005
SUMMARY Target of rapamycin (TOR) proteins are members of the phosphatidylinositol kinase-related kinase (PIKK) family and are highly conserved from yeast to mammals. TOR proteins integrate signals… Expand
Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells
- N. S. Wickramasinghe, Tissa T. Manavalan, Susan M. Dougherty, Krista A. Riggs, Y. Li, C. Klinge
- Biology, Medicine
- Nucleic acids research
- 5 March 2009
Select changes in microRNA (miRNA) expression correlate with estrogen receptor α (ERα) expression in breast tumors. miR-21 is higher in ERα positive than negative tumors, but no one has examined how… Expand
Apoptosis and the target genes of microRNA-21
MicroRNA-21 (miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors. Through functional suppression, miR-21 is implicated in practically every… Expand
Role of matrix metalloproteinases in skeletal muscle
Matrix metalloproteases (MMPs) are key regulatory molecules in the formation, remodeling, and degradation of extracellular matrix (ECM) components in both physiological and pathological processes in… Expand