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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip,Expand
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A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin.
  • Yang Wang, Y. Lv, +17 authors J. Shen
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
  • 1 August 2015
OBJECTIVES The oxazolidinone-resistant Enterococcus faecalis E349 from a human patient tested negative for the cfr gene and 23S rRNA mutations. Here we report the identification of a novelExpand
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Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization.
BACKGROUND & AIMS The immunoinhibitory receptor programmed death-1 (PD-1) is up-regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and blockade of PD-1/PD-ligandExpand
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Nano-CeO2 exhibits adverse effects at environmental relevant concentrations.
Ceria nanoparticles (nano-CeO(2)), due to their widespread applications, have attracted a lot of concern about their toxic effects on both human health and the environment. The present work aimed toExpand
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A comprehensive molecular study on Coffin-Siris and Nicolaides-Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling.
Chromatin remodeling complexes are known to modify chemical marks on histones or to induce conformational changes in the chromatin in order to regulate transcription. De novo dominant mutations inExpand
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Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.
Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and results in severeExpand
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Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans
  • T. He, Ran Wang, +25 authors Yang Wang
  • Biology, Medicine
  • Nature Microbiology
  • 27 May 2019
Tigecycline is a last-resort antibiotic that is used to treat severe infections caused by extensively drug-resistant bacteria. tet(X) has been shown to encode a flavin-dependent monooxygenase thatExpand
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DCGL v2.0: An R Package for Unveiling Differential Regulation from Differential Co-expression
Motivation Differential co-expression analysis (DCEA) has emerged in recent years as a novel, systematic investigation into gene expression data. While most DCEA studies or tools focus on theExpand
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Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia.
Hypoxia-inducible factors (HIFs) play key roles in the cellular response to hypoxia. It is widely accepted that whereas HIF-1 and HIF-2 function as transcriptional activators, HIF-3 inhibits HIF-1/2αExpand
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Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring.
Perfluorooctane sulfonate (PFOS) could induce neonatal pulmonary injuries in rodents. The aim of this study was to investigate the underlying mode of action. Pregnant rats were dosed orally with PFOSExpand
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