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Structure of Crumbs tail in complex with the PALS1 PDZ–SH3–GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex
Significance The Crumbs–PALS1–PATJ complex is vital for the development and maintenance of the polarity of diverse tissues. Defects in Crumbs–PALS1–PATJ complex formation are known to cause diseasesExpand
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OsPT2, a phosphate transporter, is involved in the active uptake of selenite in rice
Selenite is a predominant form of selenium (Se) available to plants, especially in anaerobic soils, but the molecular mechanism of selenite uptake by plants is not well understood. ltn1, a riceExpand
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Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4DCAF1. Numerous mutations of Merlin have beenExpand
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Structural Basis for the Phosphorylation-regulated Interaction between the Cytoplasmic Tail of Cell Polarity Protein Crumbs and the Actin-binding Protein Moesin*
Background: Crumbs functions in cell growth control via its short cytoplasmic tail. Results: The structure of the crumbs cytoplasmic tail in complex with moesin protein 4.1/ezrin/radixin/moesinExpand
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The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice.
The miR-17-92 cluster and its 6 encoded miRNAs are frequently amplified and aberrantly expressed in various malignancies. This study demonstrates that retroviral-mediated miR-17-92 overexpressionExpand
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The Negative c-Myc Target Onzin Affects Proliferation and Apoptosis via Its Obligate Interaction with Phospholipid Scramblase I
ABSTRACT Onzin, the product of a negatively c-Myc-regulated target gene, is highly expressed in myeloid cells. As a result of its interaction with and activation of Akt1 and Mdm2, onzinExpand
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Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt–Mdm2–p53 pathway
The c-Myc oncoprotein is a general transcription factor whose target genes dictate the c-Myc phenotype. One such target of c-Myc, ‘onzin’, is normally expressed at high levels in myeloid cells and isExpand
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The Ever Expanding Role for c-Myc in Promoting Genomic Instability
Genomic instability (GI) is a hallmark of many cancers. GI is believed toconfer upon impending neoplastic cells the ability to accumulate all of therequisite mutations for transformation within theExpand
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A c‐Myc‐MicroRNA functional feedback loop affects hepatocarcinogenesis
c‐Myc (Myc) plays an important role in normal liver development and tumorigenesis. We show here that Myc is pathologically activated in and essential for promoting human hepatocellular carcinomaExpand
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Retroviral insertional activation of the Fli-3 locus in erythroleukemias encoding a cluster of microRNAs that convert Epo-induced differentiation to proliferation.
MicroRNAs (miRNAs) are a newly discovered class of posttranscriptional regulatory noncoding small RNAs. Recent evidence has shown that miRNA misexpression correlates with progression of various humanExpand
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