Autoradiography of P2X ATP receptors in the rat brain
- V. Balcar, Y. Li, S. Killinger, M. Bennett
- Biology, ChemistryBritish Journal of Pharmacology
- 1 May 1995
The highest density of P2x binding sites was found to be in the cerebellar cortex but the binding sites were present in all major brain regions, especially in areas known to receive strong excitatory innervation.
Agonist-induced photoincorporation of a p-benzoylphenylalanine derivative of substance P into membrane-spanning region 2 of the Torpedo nicotinic acetylcholine receptor delta subunit.
- M. P. Blanton, Y. Li, E. R. Stimson, J. Maggio, J. B. Cohen
- Biology, ChemistryMolecular Pharmacology
- 1 December 1994
It is established that in the presence of agonist at least a part of the undecapeptide substance P binds within the ion channel in the desensitized state of the AChR, and it is likely that the binding of substance P to this site is responsible for the action of Substance P as a noncompetitive A ChR antagonist.
Heterogeneity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system.
Local anesthetics inhibit substance P binding and evoked increases in intracellular Ca2+.
Results are consistent with a direct action of local anesthetics on tachykinin-mediated neurotransmission during regional anesthesia because millimolar concentrations of localAnesthetics are within the range measured in spinal cord during intrathecal and epidural procedures.
Sensitivity of the binding sites on glutamate transporters to neurotoxic agents.
It is concluded that the substrate-binding sites on Na(+)-dependent glutamate transporters are relatively resistant to direct effects of Zn2+, NH4+ and free radicals but they may depend on the structural integrity of thiol bonds.
Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA),…
Neither of the compounds had any important effect at the "non-NMDA" receptor binding sites but L-t-3OHA was a weak inhibitor of [3H]CGP 39653 binding (< 40% at 100 microM).