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A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants.
HopAI1, an effector widely conserved in both plant and animal bacterial pathogens, inhibits the Arabidopsis mitogen-activated protein kinases (MAPKs) activated by exposure to PAMPs, uncovering a mechanism by which Pseudomonas syringae overcomes host innate immunity to promote pathogenesis. Expand
New World Bats Harbor Diverse Influenza A Viruses
Using consensus degenerate RT-PCR, a novel influenza A virus is identified in a flat-faced fruit bat from Peru, indicating that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses. Expand
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
The results provide evidence that circular RNA produced from precursor mRNA may have a regulatory role in human cells and characterize one abundant circRNA derived from Exon2 of the HIPK3 gene, termed circHIPK3. Expand
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling
It is shown that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration pattern of newborn granule cells, depending on the time of birth in relation to the epileptic insult. Expand
Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation
It is shown that YopJ acted as an acetyltransferase, using acetyl–coenzyme A (CoA) to modify the critical serine and threonine residues in the activation loop of MAPKK6 and thereby blocking phosphorylation. Expand
AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling
It is found that VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5′-monophosphate (AMP), which prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. Expand
Soybean Aphid Resistance in Soybean Jackson Is Controlled by a Single Dominant Gene
Results indicated that a single dominant gene controlled resistance in Jackson, a cultivar found to have strong antibiosis-type resistance to the soybean aphid, and there is no known genetic relationship between Jackson and Dowling. Expand
Identification of a Novel Astrovirus (Astrovirus VA1) Associated with an Outbreak of Acute Gastroenteritis
ABSTRACT The etiology of a large proportion of gastrointestinal illness is unknown. In this study, random Sanger sequencing and pyrosequencing approaches were used to analyze fecal specimens from aExpand
Characterization of Human Metapneumoviruses Isolated from Patients in North America
Sequence studies of the nucleocapsid, fusion, and polymerase genes identified 2 main lineages of HMPV and cocirculation of both lineages during the same year. Expand
A decade’s studies on metastasis of hepatocellular carcinoma
A molecular signature that can classify metastatic HCC patients is generated, osteopontin is identified as a lead gene in the signature, and it is found that genes favoring metastasis progression were initiated in the primary tumors. Expand