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Characterization of the Saccharomyces cerevisiae RTA1 gene involved in 7-aminocholesterol resistance
The RTA1 gene, which encodes a putative protein with seven potential membrane-spanning segments, was shown to be a non-essential gene in yeast and led to strong resistance to the inhibitor 7-aminocholesterol.
Squalamine: An Appropriate Strategy against the Emergence of Multidrug Resistant Gram-Negative Bacteria?
It is demonstrated that squalamine appears as an alternate way to combat MDR pathogens and by pass the gap regarding the failure of new active antibacterial molecules.
[Diterpene ketols with antimicrobial activity from Bifurcaria bifurcata (author's transl)].
Synthesis and antifungal activity of cholesterol-hydrazone derivatives.
Cell binding, uptake and cytosolic partition of HIV anti-gag phosphodiester oligonucleotides 3'-linked to cholesterol derivatives in macrophages.
Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors.
Two novel alpha-conotoxins were purified and characterized from the venom of the fish-hunting cone snail Conus consors. These peptides were identified by screening HPLC fractions of the crude venom…
A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+‐dependent mechanism
It is suggested that CcTx, by specifically activating neuronal voltage‐gated sodium channels at the resting membrane potential, produced Na+ entry into nerve terminals and axons without directly affecting skeletal muscle fibres.
Recent Advances in the Synthesis of Spermine and Spermidine Analogs of the Shark Aminosterol Squalamine
Great attention has recently been focused on the shark aminosterol squalamine (1) because of its important antimicrobial and antiangiogenic activities. Herein, we present the different series of…
In‐vitro evaluation of filaricidal activity of GABA and 1,3‐dipalmitoyl‐2‐(4‐aminobutyryl)glycerol HCl: a diglyceride prodrug
- J. Deverre, P. Loiseau, P. Couvreur, Y. Letourneux, P. Gayral, J. Benoit
- BiologyThe Journal of pharmacy and pharmacology
- 1 March 1989
A diglyceride ester of γ‐aminobutyric acid (GABA) has been synthesized and its filaricidal activity compared with GABA, and progabide in‐vitro, on infective larvae and microfilariae of Molinema dessetae, a rodent filaria, confirms filariae sensitivity to GABA derivatives.