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Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling
TLDR
It is observed that gut colonization of mice by a strain of Escherichia coli prevents wasting triggered by infections or physical damage to the intestine, which promotes tolerance to diverse diseases.
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues
TLDR
It is demonstrated that mmBCFAs are de novo synthesized via mitochondrial BCAA catabolism, exported to the cytosol by adipose-specific expression of carnitine acetyltransferase (CrAT), and elongated by FASN.
Reduced inflammatory responses to poly(lactic-co-glycolic acid) by the incorporation of hydroxybenzyl alcohol releasing polyoxalate
TLDR
Developing PLGA blend films containing HBA-incorporated peroxalate polymer (HPOX) and investigating the effects of HPOX on the local inflammatory responses to PLGA found that PLGA/HPOX blend films implanted into a rat had significantly diminished inflammatory responses.
Reduction of inflammatory responses and enhancement of extracellular matrix formation by vanillin-incorporated poly(lactic-co-glycolic acid) scaffolds.
TLDR
Based on the low level of inflammatory responses and enhanced ECM formation, vanillin-incorporated PLGA constructs make them promising candidates in the future biomedical applications.
Decoding the intestinal epithelium cell by cell
Single-cell sequencing identifies novel subtypes of intestinal epithelial cells and their molecular signatures, which reveals new principles for gut homeostasis and the response to infection.
Effects of PLGA/Fibrin Scaffolds on Attachment and Proliferation of Costal Cartilage Cells
TLDR
Fibrin incorporated PLGA scaffolds were prepared to evaluate the effects of fibrin on the cell attachment and proliferation in vitro and in vivo and confirmed that proliferation of cells in PLGA/fibrin scaffolding were better than in PL GA scaffolds.
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