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Robust Airline Scheduling Under Block-Time Uncertainty
Airline schedule development continues to remain one of the most challenging planning activities for any airline. An airline schedule comprises a list of flights and specifies the origin,Expand
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Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling
Tyrosinase is involved in melanin biosynthesis and the abnormal accumulation of melanin pigments leading to hyperpigmentation disorders that can be treated with depigmenting agents. A natural productExpand
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Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface
Protein-protein interactions are critical determinants in biological systems. Engineered proteins binding to specific areas on protein surfaces could lead to therapeutics or diagnostics for treatingExpand
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A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies.
Computational chemistry is playing an increasingly important role in drug design and discovery, structural biology, and quantitative structure-activity relationship (QSAR) studies. For QSAR work,Expand
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Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments.
Protein loops are frequently considered as critical determinants in protein structure and function. Recent advances in high-throughput methods for DNA sequencing and thermal stability measurementExpand
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A Novel algorithm of local contrast enhancement for medical image
The local contrast enhancement of medical image is useful and important to the medicine diagnosis. The current techniques of local enhancing exists both over-enhancing and high complexity problems.Expand
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Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors.
Malaria, caused by infections of the human malaria parasites Plasmodium falciparum, is a global infectious parasitic disease. Each year, about three million people died from malaria and the majorityExpand
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Estimation of Pure Characteristics Demand Models with Pricing ∗
A pure characteristics model is a class of discrete-choice random-coefficients demand models in which there is no idiosyncratic logit error term in a consumer’s utility. The absence of the logitExpand
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Antibodies against Venom of the Snake Deinagkistrodon acutus
ABSTRACT Snake venom protein from Deinagkistrodon acutus (DA protein), one of the major venomous species in Taiwan, causes hemorrhagic symptoms that can lead to death. Although horse-derivedExpand
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Production and Characterization of Neutralizing Antibodies against Bungarus multicinctus Snake Venom
ABSTRACT The venom of the banded krait (Bungarus multicinctus), one of the major venomous species in Taiwan, contains neurotoxic venom proteins (B. multicinctus proteins) that pose a serious medicalExpand
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