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Natural history of thyroid function tests over 5 years in a large pediatric cohort.
TLDR
In the pediatric population, initial normal or slightly elevated TSH levels are likely to remain normal or spontaneously normalize without treatment, and patients with initial levels greater than 7.5 mIU/liter, particularly girls, are at a greater risk for sustained abnormal T SH levels.
Differentiated thyroid carcinoma in pediatric patients: comparison of presentation and course between pre-pubertal children and adolescents.
TLDR
DTC has a more aggressive presentation in pre-pubertal children and Rigorous initial surgical and I(131) treatment, followed by thyrotropin suppression, was found to result in an outcome similar to that achieved in the pubertal group.
A novel loss-of-function mutation in GPR54/KISS1R leads to hypogonadotropic hypogonadism in a highly consanguineous family.
TLDR
Underdeveloped external genitalia and impuberism point to the major role of GPR54 in the activation of the gonadotropic axis from intrauterine life to adulthood.
The Natural History of Metabolic Comorbidities in Turner Syndrome from Childhood to Early Adulthood: Comparison between 45,X Monosomy and Other Karyotypes
TLDR
The more prominent clustering of metabolic comorbidities in 45,X monosomy underscores the importance of a more vigorous intervention in this group of patients and indicates the need for careful surveillance to prevent and control obesity already from childhood.
Effect of sex hormone administration on circulating ghrelin levels in peripubertal children.
TLDR
A pharmacological increase in sex hormones is associated with a marked decline in circulating levels of ghrelin in boys but not girls, and additional longitudinal studies through puberty are needed to elucidate the physiological interaction between sex hormones and gh Relin.
A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency
TLDR
It is recommended that patients with GH deficiency and ocular malformation in whom genetic analysis for classic transcription factor genes failed to identify alterations should be checked for the presence of mutations in the OTX2 gene.
A pneumococcal protein that elicits interleukin-8 from pulmonary epithelial cells.
TLDR
The results implicate the C3-binding protein of S. pneumoniae in a novel pathway of pulmonary inflammation.
Lessons learned from the continuous glucose monitoring metrics in pediatric patients with type 1 diabetes under COVID-19 lockdown
TLDR
CGM metrics in pediatric patients with T1D were relatively stable during a nationwide lockdown, and intervention plans should focus on younger patients with lower socioeconomic position.
Association of Gestational Diabetes With Maternal Disorders of Glucose Metabolism and Childhood Adiposity
TLDR
Among women with GD identified by contemporary criteria compared with those without it, GD was significantly associated with a higher maternal risk for a disorder of glucose metabolism during long-term follow-up after pregnancy.
Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Gestational Diabetes Mellitus and Childhood Glucose Metabolism
TLDR
Offspring exposed to untreated GDM in utero are insulin resistant with limited β-cell compensation compared with offspring of mothers without GDM, and GDM is significantly and independently associated with childhood IGT.
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