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Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage
- Y. Kuwabara, K. Ono, Takeshi Kimura
- Biology, MedicineCirculation. Cardiovascular genetics
- 1 August 2011
The results suggest that elevated levels of circulating miR-133a in patients with cardiovascular diseases originate mainly from the injured myocardium, and it may have functions in cardiovascular diseases.
MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo
A critical role is established for miR-33 in the regulation of ABCA1 expression and HDL biogenesis in vivo in mice lacking microRNA (miR)-33.
MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes.
MicroRNA-33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE−/− Mice
It is demonstrated that miR-33 deficiency serves to raise HDL-C, increase cholesterol efflux from macrophages via ABCA1 and ABCG1, and prevent the progression of atherosclerosis.
MicroRNA-15b Modulates Cellular ATP Levels and Degenerates Mitochondria via Arl2 in Neonatal Rat Cardiac Myocytes*
The present results suggest that miR-15b may decrease mitochondrial integrity by targeting Arl2 in the heart and down-regulate the same target genes and consequently decrease cellular ATP levels.
MicroRNAs and cardiovascular diseases
In the present minireview, the current relevant findings on the role of miRNAs in cardiac diseases are updated and the target genes of these mi RNAs are summarized.
Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway
Findings suggested that the up-regulation of miR-146a after Dox treatment is involved in acute Dox-induced cardiotoxicity by targeting ErbB4.
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
It is shown that deletion of miR-33 results in marked worsening of high-fat diet-induced obesity and liver steatosis and a novel interaction between SRE BP-1 and SREBP-2 mediated by miR -33 in vivo is elucidated.
Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5.
The regulation of adipocyte differentiation by 5-HT, 5- HT(2A)R, and5-HT(2C)R is identified and miR-448-mediated repression of KLF5 was identified as a negative regulator for adipocytes differentiation.
MicroRNA-27a Regulates Beta Cardiac Myosin Heavy Chain Gene Expression by Targeting Thyroid Hormone Receptor β1 in Neonatal Rat Ventricular Myocytes
Findings suggested that miR-27a regulates β-MHC gene expression by targeting TRβ1 in cardiomyocytes, a bioinformatics screening using TargetScan suggested that specific miRNAs could upregulate the β- MHC gene.