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Cell-polarity dependent effect of chelation on the paracellular permeability of confluent caco-2 cell monolayers
Abstract To investigate the effect of extracellular chelation at the apical, basolateral or both sides on the resistance and permeability of epithelial cell layers, we used 15 days cultures of aExpand
Beliefs of chronically ill Japanese patients that lead to intentional non‐adherence to medication
To identify factors, associated with personal beliefs, involved in intentional non‐adherence to prescribed medication of Japanese patients with chronic diseases, and to identify factors related to personal beliefs. Expand
Prediction of the Plasma Concentration Profiles of Orally Administered Drugs in Rats on the Basis of Gastrointestinal Transit Kinetics and Absorbability
A new method based on gastrointestinal transit kinetics has been developed for estimation of the absorption profiles of drugs administered orally as aqueous solutions. The utility of the method wasExpand
Chronic angiotensin II inhibition increases levels of calcitonin gene-related peptide mRNA of the dorsal root ganglia in spontaneously hypertensive rats.
The results suggest that long-term inhibition of angiotensin II restores the reduced expression of C GRP mRNA in DRG and may facilitate neurotransmission of CGRP-containing vasodilator nerves in SHR. Expand
Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter.
Results suggested that 4-OH could be used as a biodistribution promoter and the enhancement of the blood-brain barrier (BBB) permeability of antipyrine caused by the concomitant use of 4- OH was believed to be concerned with the increase of the Kp value of antipyrsine in the brain. Expand
Mechanism of gastrointestinal absorption of glycyrrhizin in rats.
Although GZ was poorly absorbable, both GZ and GA were detected in rat plasma after oral administration of GZ, suggesting that GZ can be absorbed in both parent and metabolite forms, although their bioavailabilities were low. Expand
Drug absorption from large intestine: physicochemical factors governing drug absorption.
It was shown that the absorption rates in the small intestine tended to reach a ceiling at the high lipophilicity, and it was suggested that the paracellular route for drug penetration in the large intestine is restricted more than in thesmall intestine. Expand
Comparative study of increased plasma quinidine concentration in rats with glycerol- and cisplatin-induced acute renal failure.
It is conceivable that the plasma concentration of positively charged and liver-metabolized compounds generally increases due to hepatic elimination suppressed as renal function decreases, but the pharmacokinetic impact of suppressed hepatic Elimination is occasionally difficult to observe in some ARF model rats since it may be blurred by the influence of increased plasma AGP level. Expand
Population Pharmacokinetic Analysis of Vancomycin Using Serum Cystatin C as a Marker of Renal Function
The predictive performance of the trough serum VAN concentration for determination of the initial dose was examined by using a new model for the analysis of the population pharmacokinetic parameters and the accuracy of the prediction was statistically better than that determined by use of the Japanese nomogram-based model. Expand
Gastrointestinal absorption characteristics of glycyrrhizin from glycyrrhiza extract.
The differences in gastrointestinal absorption behaviors of glycyrrhizin between pure GZ and GZ in glycyRrhiza extract (GE) (equivalent dose as GZ) were examined in rats, and at least some of the factors in GE altering the bioavailability of GZ were identified. Expand