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Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
  • C. Wen, Y. Kuo, +12 authors N. Yang
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 31 July 2007
It is suggested that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects. Expand
Cytotoxic triterpenes from the aerial roots of Ficus microcarpa.
Compound 8 and pentacyclic triterpenes 9-15 possessing a carboxylic acid functionality at C-28 showed significant cytotoxic activities against the aforementioned cell lines and gave IC50 values in the range 4.0-9.4 microM. Expand
Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa.
Chemopreventive activities of crude and fractionated plant extracts of Bidens pilosa were evaluated in this study and a new compound, heptanyl 2-O-beta-xylofuranosyl-(1-->6)-beta-glucopyranoside, and eight phenolic compounds, namely quercetin 3-o-rabinobioside, were for the first time isolated. Expand
Ethyl caffeate suppresses NF‐κB activation and its downstream inflammatory mediators, iNOS, COX‐2, and PGE2in vitro or in mouse skin
It is suggested that the catechol moiety and α,β‐unsaturated ester group in ethyl caffeate are important and essential structural features for preventing NF‐κB·DNA complex formation. Expand
Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes.
Ellagic acid treatment significantly inhibited the UVA-induced apoptosis of HaCaT cells, as measured by a reduction of DNA fragmentation, mitochondria dysfunction, ER stress, caspase-3 activation, and Bcl-2/Bax deregulation. Expand
Larvicidal activity of tectoquinone isolated from red heartwood-type Cryptomeria japonica against two mosquito species.
Results of this study show that the methanolic extract of C. japonica sapwood may be considered as a potent source and tectoquinone as a new natural mosquito larvicidal agent. Expand
Anti-inflammatory activity of new compounds from Andrographis paniculata by NF-kappaB transactivation inhibition.
This study further isolated these active compounds from bioactivity-guided chromatographic fractionation and identified eight pure compounds, which significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide secretions from LPS/IFN-gamma stimulated RAW 264.7 cells. Expand
The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling
The profound reduction in cell number was observed in combination treatment with FKB and Akt/p 38 MAPK inhibitors, indicating that the disruption of Akt and p38 MAPK cascades plays a functional role in FKB-induced G(2)/M arrest and apoptosis in HSC-3 cells. Expand
Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines.
Treatment with EAC decreased the cell growth and induced apoptosis both in Hep G2 and PLC/PRF/5 cells. Expand
Metabolic derepression of alpha-amylase gene expression in suspension-cultured cells of rice.
We present evidence to show that the alpha-amylase gene family in rice is under two different modes of regulation: 1) hormonal regulation in germinating seeds, and 2) metabolic repression in culturedExpand