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Inhibitory effect of quercetin on carrageenan-induced inflammation in rats.
The study indicated that the flavonols modulated the inflammatory response, at least in part, by modulating the prostanoid synthesis as well as cytokine production. Expand
Structural requirements of lipid A responsible for the functions: a study with chemically synthesized lipid A and its analogues.
To confirm the revised lipid A structure of Escherichia coli and to establish the structure responsible for its functions, biological activities of the synthetic compounds based on the presented… Expand
Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen.
Results indicate that deprivation of IL-2 is deeply involved in the deletion of expanded s Ag-reactive T cells and their anergy induction in sAg-injected mice. Expand
Immunological Properties of Trehalose Dimycolate (Cord Factor) and Other Mycotic Acid‐Containing Glycolipids–‐A Review
This review tries to link well‐known properties of mycolic acid‐containing glycolipids, e.g., stimulation of cellular and humoral immunity, granuloma formation and anti‐tumor activity, with recent findings in molecular immunology and to give an outlook on potential practical applications. Expand
Primary human immunodeficiency virus type 1 viremia and central nervous system invasion in a novel hu-PBL-immunodeficient mouse strain
The results suggest that the genetic background, including innate immunity, is critical in the development of primary HIV-1 viremia and subsequent central nervous system invasion with HIV- 1 and that the hu-PBL-NOD-scid mouse represents a useful model for the study of the pathogenesis of HIV-2 in vivo, especially brain involvement, and therapy of primaryAIDS. Expand
Effects of antioxidant polyphenols on TNF-alpha-related diseases.
- K. Kawaguchi, Tsukasa Matsumoto, Y. Kumazawa
- Chemistry, Medicine
- Current topics in medicinal chemistry
- 30 June 2011
The intake of polyphenols contained in natural sources are able to modulate chronic inflammatory diseases, such as type 2 diabetes, rheumatoid arthritis, inflammatory bowel disease, and affect the formation and interaction of advanced glycation end products with their respective receptors. Expand
Structural analysis of sphingophospholipids derived from Sphingobacterium spiritivorum, the type species of genus Sphingobacterium.
- T. Naka, N. Fujiwara, +9 authors Kazuo Kobayashi
- Biology, Medicine
- Biochimica et biophysica acta
- 30 December 2003
To the authors' knowledge, the existence of CerPM-1 is a novel sphingophospholipid through eukaryotic and prokaryotic cells. Expand
Pulmonary Collectins Enhance Phagocytosis of Mycobacterium avium through Increased Activity of Mannose Receptor1
Analysis by confocal microscopy and flow cytometry revealed that the lung collectins up-regulated the cell surface expression of mannose receptor on monocyte-derived macrophages, providing compelling evidence that SP-A and SP-D enhance mannosed receptor-mediated phagocytosis of M. avium. Expand
Liposomal Lipopolysaccharide Initiates TRIF-Dependent Signaling Pathway Independent of CD14
It is clearly demonstrated that intracellular delivery of LPS by LPS-formulated liposomes (LPS-liposomes) initiate only TRIF-dependent signaling via clathrin-mediated endocytosis, independent of CD14. Expand
Importance of fatty acid substituents of chemically synthesized lipid A-subunit analogs in the expression of immunopharmacological activity
The immunopharmacological activities of chemically synthesized lipid A-subunit analogs, 4-O-phosphono-D-glucosamine derivatives carrying different N- and 3- O-linked acyl groups, were investigated and the importance of fatty acid substituents, including stereospecificity for the expression of immunophile activities, was demonstrated. Expand