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Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death.
TLDR
Upon energy depletion erythrocytes form leukotrienes, which in turn activate cation channels, leading to Ca(2+) entry, cell shrinkage and cell membrane scrambling, which participate in the signaling of eryptosis during energy depletion.
Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7
TLDR
Lack of annexin A7 sensitizes the erythrocytes for “proapoptotic” Ca2+ overload, an effect shortening the life span of the affected ery Throcytes and, thus, leading to anemia.
Modulation of suicidal erythrocyte cation channels by an AMPA antagonist
TLDR
A novel action of AMPA receptor antagonists is revealed and the possibility that GluA1 or a pharmacologically related protein participates in the regulation of Ca2+ entry into and suicidal death of human erythrocytes is raised.
Dimethyl sulfoxide at high concentrations inhibits non-selective cation channels in human erythrocytes.
TLDR
It is shown that high concentrations of DMSO inhibit the non-selective cation channels in human erythrocytes and thus protect the cells against Na+ and Ca2+ overload.
Niflumic Acid Affects Store-Operated Ca2+-Permeable (SOC) and Ca2+-Dependent K+ and Cl− Ion Channels and Induces Apoptosis in K562 Cells
TLDR
It is concluded that inhibition of SOC channels plays a major role in NA-induced apoptosis and increased apoptotic levels in Tg-treated K562 cells in the presence of NA may be due to the blockage of CAC and stimulation of SK4 channels in addition to SOC channels inhibition.
Sphingosine but not Sphingosine-1-phosphate Stimulates Suicidal Erythrocyte Death
TLDR
The observations disclose sphingosine, but not sphingoine-1-phosphate, as a strong inducer of eryptosis.
Dicoumarol Activates Ca2+-permeable Cation Channels Triggering Erythrocyte Cell Membrane Scrambling
TLDR
Dicoumarol stimulates suicidal death of erythrocytes by stimulating Ca2+ entry and subsequent triggering of 2+ dependent cell membrane scrambling.
The study of Ca2+ influx in human erythrocytes in isotonic polyethylene (glycol) 1500 (PEG-1500) and sucrose media.
TLDR
It is proposed that a change in the hydrogen environment of Ca2+ -ATPase of the erythrocytes suspended in the PEG-1500 solution is the primary cause of altered Ca2- homeostasis in these cells.
Effect of Casein Kinase 1α Activator Pyrvinium Pamoate on Erythrocyte Ion Channels
TLDR
Pyrvinium pamoate activates Cl-sensitive Ca-permeable cation channels with subsequent Ca-2+-entry and inhibits Ca-activated K-channels thus blunting the stimulating effect of Ca<sup>2+</sup> on those channels, K-exit and thus cell shrinkage.
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