Y. Kubota

Publications71
h-index23
Citations1,346
Highly Influential Citations45
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Ginkgo biloba extract markedly induces pentoxyresorufin O-dealkylase activity in rats.
We examined the effect of Ginkgo biloba extract (GBE) on hepatic drug-metabolizing enzymes, particularly cytochrome P450 (CYP), in rats. Rats were fed a GBE-containing diet or received GBE by… Expand
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Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.
Ginkgo biloba extract (GBE) has been used clinically for improving peripheral vascular diseases in France and Germany and is ingested widely as a herbal medicine in some countries. However, accurate… Expand
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Evaluation of blood pressure measured by tail-cuff methods (without heating) in spontaneously hypertensive rats.
Conventional noninvasive blood pressure in conscious rats or mice are typically measured using the tail-cuff method after heating the animal. The goal of this study was to assess the validity of a… Expand
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Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level.
Ginkgo biloba extract (GBE) has been used clinically for improving peripheral vascular diseases in France and Germany. In the present study, to clarify the pharmacological properties of vasodilation… Expand
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Pretreatment with Ginkgo biloba extract weakens the hypnosis action of phenobarbital and its plasma concentration in rats
In a previous study, we found that orally administered Ginkgo biloba extract (GBE) induced hepatic cytochrome P450 (CYP) in rats, especially the CYP2B type. This fact suggested that GBE influenced… Expand
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Induction and recovery of hepatic drug metabolizing enzymes in rats treated with Ginkgo biloba extract.
Herb-drug interactions, especially cytochrome P450 (CYP)-mediated interactions, cause an enhancement or attenuation in efficacy of co-administered drugs. In a previous study, we reported that… Expand
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Peroxynitrite is Involved in the Dysfunction of Vasorelaxation in SHR/NDmcr-cp Rats, Spontaneously Hypertensive Obese Rats
SHR/NDmcr-cp (SHR-cp) rats display typical symptoms and features of the metabolic syndrome. We previously reported that endothelium-dependent relaxation decreases in the thoracic aortas of SHR-cp… Expand
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Isolation and characterization of cyclic α-(1→4)-glucans having degrees of polymerization 9–31 and their quantitative analysis by high-performance anion-exchange chromatography with pulsed…
Abstract Cyclic α-(1→4)-glucans with degrees of polymerization (DPs) 9–31 were isolated from a mixture of cyclization products formed in the early stage of the action of cyclodextrin… Expand
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Effects of Ginkgo biloba extract on blood pressure and vascular endothelial response by acetylcholine in spontaneously hypertensive rats
We previously demonstrated that Ginkgo biloba extract (Ginkgo) produced vasodilation via the nitric oxide pathway in aortic segments isolated from Wistar rats. In this study, we have analysed the… Expand
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ANTI‐HYPERTENSIVE EFFECTS OF BRAZILIAN PROPOLIS IN SPONTANEOUSLY HYPERTENSIVE RATS
1. Changes in the cardiovascular parameters of Wistar–Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were examined following a 4‐week diet of either Brazilian propolis or Eucommia uloides… Expand
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