• Publications
  • Influence
Study on fluorination of 2,3-dideoxy-2,3-(N-tosylepimino)-alpha-D-allopyranosides, and synthesis of 3'-deoxy-3'-fluorokanamycin B and 3',4'-dideoxy-3'-fluorokanamycin B.
Reaction of the structurally rigid methyl 2,3-dideoxy-4,6-O-isopropylidene-2,3-(N-tosylepimino)-alpha-D-a llopyranoside with KHF2 with a slightly different reaction mechanism for the mobile compounds has been proposed and both compounds were active against resistant bacteria producing 3'-modifying enzymes. Expand
Synthesis of 4'-deoxy-4'-fluorokanamycin A and B.
Both 17 and 25 were active against resistant bacteria producing aminoglycoside-adenylylating enzymes for HO-4' and the mechanism of this reaction is discussed. Expand
Synthesis of 5-deoxy-5-fluoro- and 5-deoxy-5,5-difluoro-netilmicin.
5-Deoxy-5-fluoro- (9) and 5-deoxy-5,5-difluoro-netilmicin (27) have been prepared from the corresponding 5-epi and 5-oxo derivatives of netilmicin by treatment with DAST. Structures of theExpand
Interunit, through-space 1H-19F and 13C-19F spin-spin couplings of 5-fluorinated arbekacins.
Two compounds showed interunit, through-space 1H-19F spin-spin couplings at the signals for H-1', 4", 5", 6"a and 6"b with F-5eq and these couplings were corroborated by 1D 13C[1H]-[19F] triple-resonance techniques. Expand