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Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1.
The human T-cell leukemia virus type I (HTLV-I), which infects a wide variety of mammalian cells including monocytes and macrophages, encodes a transactivating protein designated as Tax. We now… Expand
Monocyte expression of the human prointerleukin 1 beta gene (IL1B) is dependent on promoter sequences which bind the hematopoietic transcription factor Spi-1/PU.1.
- Y. Kominato, D. Galson, W. Waterman, A. Webb, P. Auron
- Biology, Medicine
- Molecular and cellular biology
- 1 January 1995
Interleukin-1 beta (IL-1 beta) is produced primarily by stimulated monocytes, suggesting that the IL1B gene, which codes for this protein, depends upon at least one cell-type-specific factor. Our… Expand
Reduced expression of human mismatch repair genes in adult T‐cell leukemia
- H. Morimoto, J. Tsukada, Y. Kominato, Y. Tanaka
- Medicine, Biology
- American journal of hematology
- 1 February 2005
In this study, we investigated the expression of six human DNA mismatch repair (MMR) genes, human MutS homologues 2 (hMSH2), 3 (hMSH3), and 6 (hMSH6), human MutL homologue 1 (hMLH1), human… Expand
Expression of ABO blood-group genes is dependent upon an erythroid cell-specific regulatory element that is deleted in persons with the B(m) phenotype.
The ABO blood group is of great importance in blood transfusion and organ transplantation. However, the mechanisms regulating human ABO gene expression remain obscure. On the basis of DNase… Expand
Autocrine Induction of the Human Pro-IL-1β Gene Promoter by IL-1β in Monocytes
- Yoko Toda, J. Tsukada, M. Misago, Y. Kominato, P. Auron, Y. Tanaka
- The Journal of Immunology
- 15 February 2002
IL-1β is produced primarily by activated monocytes/macrophages. We report in this study that IL-1β induces the human pro-IL-1β (IL1B) gene promoter in human THP-1 monocytic cells. The −131 to +12… Expand
Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1
- F. Mouri, J. Tsukada, +7 authors Y. Tanaka
- Biology, Medicine
- European journal of haematology
- 4 October 2007
High mobility group box 1 protein (HMGB1), originally described as a non‐histone, DNA binding protein, was recently identified as a late mediator of inflammation via its extracellular release from… Expand
Autocrine induction of the human pro-IL-1beta gene promoter by IL-1beta in monocytes.
IL-1beta is produced primarily by activated monocytes/macrophages. We report in this study that IL-1beta induces the human pro-IL-1beta (IL1B) gene promoter in human THP-1 monocytic cells. The -131… Expand
Human hypoxic signal transduction through a signature motif in hepatocyte nuclear factor 4.
We identified a human hypoxic signal transduction pathway acting through a signature motif in the carboxyl terminal of hepatocyte nuclear factor 4 (HNF-4), by functional comparison of the… Expand
α1,2Fucosylation Is a Superior Predictor of Postoperative Prognosis for Colorectal Cancer Compared with Blood Group A, B, or Sialyl Lewis X Antigen Generated within Colorectal Tumor Tissues
BackgroundWe have previously demonstrated tumor-specific α1,2fucosylation, which is associated with resistance of tumor cells to anticancer treatment in human colorectal tumor tissues. By using the… Expand
in negative regulation of gene expression
Gene expression is driven by promoters, enhancers, silencers, and other cis-regulatory elements upstream and downstream of the gene. Previous studies of the regulation of human ABO gene transcription… Expand