Production of superoxide radical in reductive metabolism of a synthetic food-coloring agent, indigocarmine, and related compounds.
- Y. Kohno, S. Kitamura, Tsuyoshi Yamada, K. Sugihara, S. Ohta
- Biology, ChemistryLife Science
- 24 June 2005
Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.
- Y. Kohno, S. Kitamura, S. Sanoh, K. Sugihara, N. Fujimoto, S. Ohta
- Chemistry, BiologyDrug Metabolism And Disposition
- 2005
When chalcone and trans-4-phenyl-3-buten-2-one (PBO) were incubated with liver microsomes of untreated rats in the presence of NADPH, 4-hydroxychalcone and trans-4-(4-hydroxyphenyl)-3-buten-2-one…
METABOLISM OF THE α,β-UNSATURATED KETONES, CHALCONE AND TRANS-4-PHENYL-3-BUTEN-2-ONE, BY RAT LIVER MICROSOMES AND ESTROGENIC ACTIVITY OF THE METABOLITES
- Y. Kohno, S. Kitamura, S. Sanoh, K. Sugihara, N. Fujimoto, S. Ohta
- Chemistry, BiologyDrug Metabolism And Disposition
- 1 August 2005
When chalcone and trans-4-phenyl-3-buten-2-one (PBO) were incubated with liver microsomes of untreated rats in the presence of NADPH, 4-hydroxychalcone and trans-4-(4-hydroxyphenyl)-3-buten-2-one…
Reductive Metabolism of an α,β-Ketoalkyne, 4-Phenyl-3-Butyn-2-One, by Rat Liver Preparations
- S. Kitamura, Y. Kohno, Y. Okamoto, M. Takeshita, S. Ohta
- Chemistry, Biology
- 1 April 2002
Results suggested that the triple-bond reduction is caused by a new type of reductase, not cytochrome P450, and the microsomal and cytosolic carbonyl reduct enzyme activities were not inhibited by quercitrin, indomethacin, or phenobarbital.
Reductive metabolism of an alpha,beta-ketoalkyne, 4-phenyl-3-butyn-2-one, by rat liver preparations.
- S. Kitamura, Y. Kohno, Y. Okamoto, M. Takeshita, S. Ohta
- Chemistry, BiologyDrug Metabolism And Disposition
- 2002
Results suggested that the triple-bond reduction is caused by a new type of reductase, not cytochrome P450, and the microsomal and cytosolic carbonyl reduct enzyme activities were not inhibited by quercitrin, indomethacin, or phenobarbital.
Reduction of aromatic nitroalkenes with baker's yeast
- M. Takeshita, S. Yoshida, Y. Kohno
- Chemistry
- 1994
Aromatic nitroalkenes were reduced chemoselectively with baker's yeast to give the corresponding nitroalkanes
- KETOALKYNE , 4-PHENYL-3-BUTYN-2ONE , BY RAT LIVER PREPARATIONS
- S. Kitamura, Y. Kohno, Y. Okamoto, M. Takeshita, S. Ohta
- Chemistry, Biology
- 2002
The results suggested that the triple-bond reduction is caused by a new type of reductase, not cytochrome P450, and may be related to genotoxicity and mutagenicity in humans and animals.
Reduction of Aromatic Nitroalkenes with Bakers′ Yeast.
- M. Takeshita, S. Yoshida, Y. Kohno
- Chemistry
- 19 August 2010
Chalcone and Trans-4-phenyl-3-buten-2one , by Rat Liver Microsomes and Estrogenic Activity of the Metabolites
- Y. Kohno, S. Kitamura, S. Sanoh, K. Sugihara, N. Fujimoto, S. Ohta
- Chemistry, Biology
- 2005
When chalcone and trans-4-phenyl-3-buten-2-one (PBO) were incubated with liver microsomes of untreated rats in the presence of NADPH, 4-hydroxychalcone and trans-4-(4-hydroxyphenyl)-3buten-2-one…