• Publications
  • Influence
P/Q-Type Calcium-Channel Blockade in the Periaqueductal Gray Facilitates Trigeminal Nociception: A Functional Genetic Link for Migraine?
TLDR
It is demonstrated that P/Q-type calcium channels in the PAG play a role in modulating trigeminal nociception and suggest a role for dysfunctional P/ Q-typecium channels in migraine pathophysiology. Expand
Inhibition of trigeminal neurones after intravenous administration of naratriptan through an action at 5‐hydroxy‐tryptamine (5‐HT1B/1D) receptors
TLDR
It is established that naratriptan acts on central trigeminal neurones since sagittal sinus stimulation activates axons within the tentorial nerve and there are no inhibitory effects mediated within the trigemINAL ganglion. Expand
Activation of 5‐HT1B/1D receptor in the periaqueductal gray inhibits nociception
TLDR
The results suggest that 5‐HT1B/1D receptor activation in the vlPAG activates descending pain‐modulating pathways that inhibit dural, but not facial and corneal nociceptive input, suggesting that brain loci other than the trigeminal nucleus may play a role in the clinical action of triptans. Expand
Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area
TLDR
The results support the role of the PH in the nociceptive processing of meningeal input as orexinergic mechanisms in the PH may provide a link for endocrine and autonomic changes as well as nocICEptive phenomena seen in primary headache disorders. Expand
The periaqueductal grey matter modulates trigeminovascular input: a role in migraine? 1 1 Presented in part at the Xth International Headache Congress, Barcelona, Spain, 24–26 June 1999
TLDR
Data support the notion that brainstem dysfunction might lead to disinhibition of trigeminal afferents and be important in the pain process of migraines and demonstrate that a role of the PAG is to inhibit afferent trigEMinal nociceptive traffic. Expand
Stimulation of an intracranial trigeminally-innervated structure selectively increases cerebral blood flow 1 These data were presented in part at the XVIIth International Symposium on Cerebral
TLDR
The more focused effects of superior sagittal sinus suggest a highly organised somatotopic arrangement of the trigeminal innervation of the cranial circulation, which may be important in understanding the pathophysiology of migraine, cluster headache and subarachnoid haemorrhage. Expand
Stimulation of the greater occipital nerve increases metabolic activity in the trigeminal nucleus caudalis and cervical dorsal horn of the cat
TLDR
The data suggest that the well recognised clinical phenomenon of pain at the front and back of the head and in the upper neck are likely to be a consequence of overlap of processing of nociceptive information at the level of the second order neurons. Expand
Occipital afferent activation of second order neurons in the trigeminocervical complex in rat
TLDR
A model for examining trigeminocervical complex activity after occipital afferent stimulation in the rat is introduced and involvement of glutamatergic NMDA receptors at this important synapse is demonstrated. Expand
Substance P blockade with the potent and centrally acting antagonist GR205171 does not effect central trigeminal activity with superior sagittal sinus stimulation 1 These data were presented in
TLDR
Data from this study suggest that neurokinin-1 blockade alone will not be an effective anti-migraine strategy, and that further data will be required to assess whether neurokin in-1 antagonists will have any more general value in pain. Expand
Blockade of calcitonin gene-related peptide release after superior sagittal sinus stimulation in cat: a comparison of avitriptan and CP122,288
TLDR
It is demonstrated that the potent inhibitor of PPE, CP122, 288, which has been shown in clinical trials to be ineffective in treating acute migraine attacks, had no effect on CGRP release, whereas the effective anti-migraine drug and relatively impotent inhibitor ofPPE, avitriptan, blocked C GRP release. Expand
...
1
2
3
...