V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity
- T. Koshimizu, Y. Nasa, G. Tsujimoto
- Biology, MedicineProceedings of the National Academy of Sciences…
- 16 May 2006
Results indicate that the V1a receptor plays an important role in normal resting arterial BP regulation mainly by its regulation of circulating blood volume and baroreflex sensitivity.
Fatty Acid Synthase Is a Key Target in Multiple Essential Tumor Functions of Prostate Cancer: Uptake of Radiolabeled Acetate as a Predictor of the Targeted Therapy Outcome
It is demonstrated that uptake of radiolabeled acetate is a useful predictor of FASN-targeted therapy outcome, which suggests that [1-11C]acetate positron emission tomography (PET) could be a powerful tool to accomplish personalized FASn- targeted therapy by non-invasive visualization of tumor acetate uptake and selection of responsive tumors.
Cytosolic acetyl‐CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl‐CoA/acetate metabolism
It is found that tumor cells expressed higher levels of cytosolic acetyl‐CoA synthetase (ACSS2) under hypoxia than normoxia, which indicates that ACSS2 is a bi‐directional enzyme in tumor cells and that AC SS2 might play a buffering role in tumor acetyl-CoA/acetate metabolism.
The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation.
Synthesis and evaluation of radioiodinated (S,S)-2-(α-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter
- N. Kanegawa, Y. Kiyono, H. Saji
- Biology, ChemistryEuropean Journal of Nuclear Medicine and…
- 8 March 2006
The synthesis of (S,S)-123I-IPBM is a potential SPECT radiopharmaceutical for imaging brain NET and shows high affinity and selectivity for NET in the binding assay experiments.
Cytotoxic effects of γδ T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy
Findings show that ZOL significantly stimulated the proliferation of gdγδT cells and that gdβδ T cells required pre‐treatment with ZOL for cytotoxic activity against target cells.
Evaluation of radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine as a ligand for brain norepinephrine transporter imaging.
Reduced 125I-meta-iodobenzylguanidine uptake and norepinephrine transporter density in the hearts of mice with MPTP-induced parkinsonism.
Functional Images Reflect Aggressiveness of Endometrial Carcinoma: Estrogen Receptor Expression Combined with 18F-FDG PET
Endometrial carcinoma reduces estrogen dependency with accelerated glucose metabolism as it progresses to a higher stage or grade through a new index of the 18F-FDG–to–18F-FES ratio, which is considered the most informative index reflecting tumor aggressiveness.
Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy.
Findings show that ZOL significantly stimulated the proliferation of gammadeltaT cells and that gammad deltaT cells required pre-treatment with ZOL for cytotoxic activity against target cells.