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Seven New Loci Associated with Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborativeExpand
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Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population
Article abstract—We followed 828 nondemented residents of Hisayama Town, Kyushu, Japan, aged 65 years or older (88.3% of the elderly population) for 7 years starting in 1985 in order to determine theExpand
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Prevalence of chronic kidney disease in the Japanese general population
BackgroundWe previously estimated the prevalence of chronic kidney disease (CKD) stages 3–5 at 19.1 million based on data from the Japanese annual health check program for 2000–2004 using theExpand
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Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease
BackgroundAccurate estimation of the glomerular filtration rate (GFR) is crucial for the detection of chronic kidney disease (CKD). In clinical practice, GFR is estimated from serum creatinine usingExpand
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Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient
BackgroundThe number of patients with end-stage renal disease (ESRD) in Japan has continuously increased in the past three decades. In 2005, 36 063 patients whose average age was 66 years entered aExpand
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C-reactive protein, fibrinogen, and cardiovascular disease prediction.
BACKGROUND There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events. METHODS WeExpand
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Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study
Diabetes mellitus (DM) is considered to be a risk factor for dementia including Alzheimer's disease (AD). However, the molecular mechanism underlying this risk is not well understood. We examinedExpand
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Metabolic syndrome and CKD in a general Japanese population: the Hisayama Study.
BACKGROUND Metabolic syndrome has been linked with various atherosclerotic diseases, but has not been evaluated sufficiently as a risk factor for the development of chronic kidney disease (CKD) inExpand
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Prevalence of age related maculopathy in a representative Japanese population: the Hisayama study
AIM To determine the prevalence of age related maculopathy (ARM) in a representative older Japanese population. METHODS 1486 residents of Hisayama town, Fukuoka, Japan, aged 50 years or older wereExpand
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A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction
Cerebral infarction is the most common type of stroke and often causes long-term disability. To investigate the genetic contribution to cerebral infarction, we conducted a case-control study usingExpand
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